Mikhail Berezin, Ph.D.

Associate Professor
Radiology
Radiological Sciences
Chemistry

Biochemistry, Biophysics, and Structural Biology Program

  • 3147470701

  • 314-747-5191

  • 8225

  • Couch Research Building, 4515 McKinley Ave, St. Louis, MO 63110

  • berezinm@WUSTL.EDU

  • http://berezinlab.wustl.edu/

  • biophysics, cancer related peripheral neuropathy, optical imaging and spectroscopy instrumentation

  • Investigation the mechanism of peripheral neuropathies

Research Abstract:

Dr. Berezin’s lab focuses on the development of understanding the mechanisms of peripheral neuropathies using imaging, electrophysiological, analytical and genetic techniques. Our current research is looking at the mechanism of chemotherapy-induced peripheral neuropathy (CIPN); a devastating, painful side effect of cancer therapy that occurs in almost 40% of patients. Our approach is based on studying the effect of chemotherapy drugs on animal models and investigating reactive oxygen species (ROS) that are implicated in the nerve inflammation. Although neurons have endogenous mechanisms that normally repair oxidative damage, their systems can become overwhelmed when an excess of ROS accumulates, resulting in oxidative stress in the nerves, their deterioration and chronic pain. The lab also develops hyperspectral optical instrumentation and new algorithms for image analysis.

Selected Publications:

Zhou H, Tourkakis G, Shi D, Kim DM, Zhang H, Du T, Eades WC, Berezin MY,* Cell-free measurements of brightness of fluorescently labeled antibodies, Scientific reports, 2017, 7, 41819

Zhang H, Salo D, Kim D, Komarov S, Tai Y-C, Berezin MY,* Penetration depth of photons in biological tissues from hyperspectral imaging in SWIR in transmission and reflection geometries, J. Biomed. Opt. 2016, 21(12), 126006

He S, Tourkakis G, Berezin OY, Gerasimchuk N, Zhang H, Israely A, Zhou H, Akers W, Berezin MY* Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery, J. Mater. Chem. C, 2016, 4, 3028-3035

Zhou H, Yan Y, Ee X, Hunter DA, Akers WJ, Wood MD, Berezin MY,* Imaging of radicals following injury or acute stress in peripheral nerves with activatable fluorescent probes, Free Radical Biology & Medicine 2016, 101, 85–92

Kim DM, Zhang H, Zhou H, Du T, Wu Q., Mockler T, Berezin MY,* Highly sensitive image-derived indices of water-stressed plants using hyperspectral imaging in SWIR and histogram analysis, Scientific Reports, 2015, 5, 15919

Cao Q, Zhegalova NG, Wang ST, Akers WJ, Berezin MY*, Multi-spectral imaging in the extended NIR window based on endogenous chromophores, J. Biomed. Optics, 2013, 18(1), 016013

Wang ST, Zhegalova NG, Gustafson TP, Zhou, A., Sher, J, Achilefu S., Berezin, OY., Berezin MY*., Sensitivity of activatable ROS probes by fluorescence spectroelectrochemistry, Analyst, 2013, 138, 4363-4369

Magalotti S, Gustafson TP, Cao Q, Abendschein D, Pierce R, Berezin MY*, Akers WJ, Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors, Mol. Imaging Biol, 2013, 15 (4), 423-430

Gustafson TP, Yan P, Newton P, Hunter DA, Achilefu S, Akers WJ, Mackinnon SE, Johnson PJ, Berezin MY,* A NIR dye for development of peripheral nerve targeted probes, MedChemCommun, 2012, 3, 685-690

Last Updated: 8/2/2018 2:20:03 PM

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