Peter Nagele, M.D., MSc.

Associate Professor
Anesthesiology
Clinical & Translational Research

Human and Statistical Genetics Program

  • 314-362-5129

  • 314-362-8571

  • 8054

  • NAGELEP@WUSTL.EDU

  • http://www.anest.wustl.edu

  • drug and target discovery, drug mechanisms, drug treatment, genetics, pharmacology, translational research

  • Perioperative Pharmacogenomics: studying the influence of genetic variation on drug use and major cardiovascular events (myocardial infarction, stroke)

Research Abstract:

The focus of Dr. Nagele’s research is on perioperative pharmacogenomics. We are interested in how the genetic background influences how patients respond to drugs and how it affects perioperative outcomes. Specifically, we study nitrous oxide (laughing gas) and genetic variation in the folate cycle and homocysteine pathway and how they relate to perioperative myocardial infarction. We also investigate how genetic variation in the adrenergic signaling pathway and the cytochrome P450 enzyme influence the efficacy and safety of beta-blocker treatment.

A second focus of Dr. Nagele’s research is hidradenitis suppurativa. Hidradenitis is a common, chronic skin disease where patients develop recurrent abscesses. It appears that hidradenitis runs in families and may be inherited. In a multidisciplinary team, we try to identify the genetic cause for hidradenitis.

Selected Publications:

Hüpfl M, Selig HF, Nagele P. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet 2010 376(9752):1552-7. PMID: 20951422

Pehböck D, Wenzel V, Voelckel W, Jonsson K, Herff H, Mittlböck M, Nagele P. Effects of Preoxygenation on Desaturation Time During Hemorrhagic Shock in Pigs. Anesthesiology 2010 113: 593–9.

Rao LK, Francis AM, Wilcox U, Miller JP, Nagele P. Preoperative B-Vitamin Infusion and Prevention of Nitrous Oxide-induced Homocysteine Increase. Anaesthesia 2010 65: 710-5.

Nagele P, Zeugswetter B, Eberle C, Hüpfl M, Mittlböck M, Födinger M. A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. Pharmacogenetics and Genomics 2009 19(5):325-9.

Nagele P, Zeugswetter B, Wiener C, Burger HJ, Hüpfl M, Mittlböck M, Födinger M. Influence of MTHFR gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology 2008 109: 36-43.

Last Updated: 8/4/2011 11:15:31 AM

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