Kelly R. Monk, Ph.D.
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program
McDonnell Science Building, 360
glia, mouse models, multiple sclerosis, nerve regeneration, neurobiology, zebrafish
Molecular and genetic mechanisms of myelination, myelin maintenance, and remyelination
The myelin sheath surrounding axons is an exquisite specialized membrane found in the vertebrate nervous system. Myelin is formed by glial cells called oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. The importance of myelin is underscored by diseases that compromise the integrity of myelinated axons, including multiple sclerosis and Charcot-Marie-Tooth disease. Despite its importance, however, relatively little is known about how the myelin sheath is formed and maintained. We are interested in the mechanisms that govern the development, maintenance, and regeneration of myelinated axons using both zebrafish and mouse models. We seek to uncover regulators of nervous system development, homeostasis, and repair.
Kueffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakrici P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilina F, Monk KR, Aguzzi A (2016) The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature 536:464-468.
Langenhan T, Piao X, Monk KR (2016) Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci 17:550-61.
Petersen SC & Monk KR (2015) Neurobiology: Myelin goes where the action is. Curr Biol 25:R562-5.
Harty BL, Krishnan A, Sanchez NE, Scioth HB, Monk KR (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics 16:62.
Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ, Mogha A, Ghidinelli M, Feltri ML, Schoenberg T, Piao X, Monk KR (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron 85:755-69.
Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with G-alpha-12/13 and RhoA. Nat Commun 6:6122.
Liebscher I, Schon J, Petersen SC, Fisher L, Auerbach N, Demberg LM, Mogha A, Coster M, Simon KU, Rothemund S, Monk KR, Schoenberg T (2014) A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133. Cell Rep 9:2018-26.
Mogha A, Benesh AE, Patra C, Engel FB, Schoenberg T, Liebscher I, Monk KR (2013) Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci 33:17976-85.
Last Updated: 8/26/2016 1:59:20 PM
A Schwann cell (yellow) myelinates an axon (pink)