Jacqueline Elise Payton, M.D., Ph.D.

Assistant Professor
Pathology and Immunology
Laboratory and Genomic Medicine

Molecular Genetics and Genomics Program

  • 314-362-5935

  • 314-362-5937

  • 8118

  • 7440 CSRB

  • jpayton@WUSTL.EDU

  • http://pathology.wustl.edu/labs/payton/

  • epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation

  • Epigenomic aberrations in B cell lymphomas and their impact on gene regulation

Research Abstract:

The Payton lab focuses on the role of aberrant epigenomic patterns in cancer-specific gene dysregulation. We take an integrative approach to understanding the complex interplay of genomic and epignomic mutations and their impact on gene regulation, employing translational, bioinformatic, and basic biological approaches to understand the progression of hematopoietic cells from healthy to malignant. In addition, we are developing sequence-specific targeted chromatin modifiers (zinc fingers, TALE, CRISPR) to reverse these pathogenic changes to the epigenomic landscape. Dr. Payton`s overarching research goal is to identify epigenomic profiles that will provide novel insights into the mechanism and pathogenesis of hematopoietic malignancy, and may ultimately pave the way for a new generation of diagnostics, prognostics, and epigenetic-based therapies.

Selected Publications:

Cancer Genome Atlas Research Network. Ley TJ, Miller C, Ding L, …Payton JE, … Wilson RK. The genomic and epigenomic landscape of adult de novo Acute Myeloid Leukemia. New England Journal of Medicine. 2013 Jul 4;369(1):98.

Perrin RJ*, Payton JE*, Malone JP, Gilmore P, Davis A, Xiong C, Fagan AM, Townsend R, Holtzman DM. Quantitative label-free proteomics for discovery of cerebrospinal fluid biomarkers: Assessment of technical and inter-individual variation. PLoS One. 2013 May 20;8(5):e64314. doi: 10.1371
*Contributed equally to authorship

Li-Wei Chang, Andreu Viader, Payton JE, Nobish Varghese, Jeffrey Milbrandt, Rakesh Nagarajan. An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury. BMC Genomics. 2013 Feb 6;14(1):84. PMID: 23387820

Spencer, David H; Abel, Haley J; Lockwood Christina M; Payton Jacqueline E; Szankasi, Philippe; Kelley, Todd W; Kulkarni, Shashikant; Pfeifer, John D; and Duncavage, Eric J. Detection of FLT3 Internal Tandem Duplication in Targeted Short Read Length Next Generation Sequencing Data. J Mol Diagn. 2013 Jan;15(1):81-93. Epub 2012 Nov 14. PMID: 23159595

Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O`Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012 Jul 20;150(2):264-78. PMID: 22817890 [PubMed - in process]

Schwarz JK, Payton JE, Rashmi R, Xiang T, Jia Y, Huettner P, Rogers BE, Yang Q, Watson MA, Rader JS, Grigsby P. Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer. Clin Cancer Res. 2012 Jan 18. [Epub ahead of print] PMID:22235101

Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012 Jan 11;481(7382):506-10. doi: 10.1038/nature10738. PMID: 22237025

Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA. POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia. 2010 Apr 8. [ePub ahead of print] PMID: 20376082

Payton JE, Schmidt J, Yu J, Lusis EA, Watson MA, Gutmann DH. Genome Wide Polymorphism Analysis Demonstrates a Monoclonal Origin of Pilocytic Astrocytoma. Neuropathol Appl Neurobiol. 2010 Jul 13. doi: 10.1111/j.1365-2990.2010.01109.x. PMID: 20646217

Ley T.J., Ding Li, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Jacqueline E. Payton, et al. DNMT3A Mutations in Acute Myeloid Leukemia. NEJM 2010 Dec 16;363(25):2424-33. PMID: 21067377

Pfeifer JD, Zehnbauer B, and Jacqueline E. Payton. The changing spectrum of DNA-based specimen provenance testing in surgical pathology. Am J Clin Pathol. 2011 Jan;135(1):132-8.PMID: 21173135

Matthew J. Walter*, Payton JE*, Rhonda E. Ries*, William D. Shannon, Hrishikesh Deshmukh, Yu Zhao Jack Baty, Sharon Heath, Peter Westervelt, Mark A. Watson, Michael H. Tomasson, Rakesh Nagarajan, Brian P. O’Gara, Clara D. Bloomfield, Krzysztof Mrozek, Rebecca R. Selzer, Todd A. Richmond, Jacob Kitzman, Joel Geogheganh, Peggy S. Eis, Rachel Maupin, Robert S. Fulton, Michael McLellan, Richard K. Wilson, Elaine R. Mardis, Daniel C. Link, Timothy A. Graubert, John F. DiPersio, and Timothy J. Ley. Acquired copy number alterations in adult acute myeloid leukemia genomes. PNAS. Published online 7/27/09. PMID: 19651600
*Co-first authors.

Last Updated: 8/27/2013 9:16:00 AM

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