Albert H. Kim, M.D., Ph.D.
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program
malignant brain tumors, glioblastoma multiforme, neural stem cells, nervous system development
Signal transduction in malignant brain tumors and brain development
Despite advances in multimodal therapies, malignant brain tumors continue to be devastating neurological diseases. The proliferation of recent genome-wide surveys of genetic and epigenetic alterations in brain tumors has led to the important identification of tumor-specific abnormalities, which are only beginning to be understood at the functional, biological level. The goal of my laboratory is to use a combined genomic and developmental approach to identify critical signaling nodes that drive malignant brain tumor growth and invasiveness. The underlying hypothesis of the research is that abnormalities in processes that govern normal neural development contribute to malignant transformation and behavior. My laboratory therefore focuses on signaling pathways in brain development and malignant brain tumors, with an emphasis on glioblastoma multiforme cancer stem cells. Potentially, these discoveries could be leveraged clinically to generate novel therapies for patients.
Puram SV,* Kim AH,*# Park H, Anckar J, Bonni A.# The Ubiquitin Receptor S5a/Rpn10 Links Centrosomal Proteasomes with Dendrite Development in the Mammalian Brain. Cell Reports. In press. (*contributed equally; #corresponding author)
S.V. Puram, A.H. Kim, Y. Ikeuchi, A. Riccio, S. Koirala, J.T. Wilson-Grady, A. Merdes, S.P. Gygi, G. Corfas, and A. Bonni. A Unique CaMKIIβ Signaling Pathway at the Centrosome Regulates Dendrite Patterning in the Mammalian Brain. Nat Neurosci. 14(8):973-83.2011.
Y. Yang, A.H. Kim, and A. Bonni. The Dynamic Ubiquitin Ligase Duo: Cdh1-APC and Cdc20-APC tag team to pattern the brain. Curr Opin Neurobiol. 20(1):92-9. 2010.
Y. Yang, A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, and A. Bonni. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326:575-8. 2009.
A.H. Kim, S.V. Puram, P.M. Bilimoria, S. Keough, M. Wong, D. Rowitch, and A. Bonni. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 136(2):322-336. 2009.
A.H. Kim and A. Bonni. Thinking within the D box: Initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci. 34(3): 281-7. 2007.
A.H. Kim, T. Sasaki, and M.V. Chao. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem 278(32): 29830-6. 2003.
A.H. Kim, H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J. Birnbaum, and M.V. Chao. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35(4): 697-709. 2002.
F.S. Lee, A.H. Kim, G. Khursigara, and M.V. Chao. The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol 11(3):281-6. 2001.
A.H. Kim, G. Khursigara, X. Sun, T.F. Franke, and M.V. Chao. Akt phosphorylates and negatively regulates Apoptosis signal-regulating kinase 1. Mol Cell Bio 21(3):893-901. 2001.
Last Updated: 7/29/2013 2:53:44 PM
Human patient-derived glioblastoma cancer stem cells with fluorescent monitor