Eynav Klechevsky, PhD

Assistant Professor
Pathology and Immunology

Immunology Program
Cancer Biology Program
Molecular Microbiology and Microbial Pathogenesis Program
Computational and Systems Biology Program

  • 314-286-0897

  • 314-747-6688

  • 8118

  • 425 South Euclid St. Louis MO

  • eklechevsky@wustl.edu

  • wupathlabs.wustl.edu/klechevsky/

  • https://twitter.com/klechevskyLab

  • Human Immunology, Dendritic Cells, Tumor Immunology, immune dysfunctions, Vaccines

  • understand the biology of different human dendritic cells and other myeloid cells as a key for manipulating immune responses in various disease conditions

Research Abstract:

The ability to distinguish between physiological and pathogenic antigens and to make decisions
about how to respond to particular pathogens or a disease condition signifies a properly functioning adaptive immune system. Dendritic cells (DCs), a diverse family of antigen presenting cells, are required to explain how these specific responses are initiated and controlled. Our work on the immune system is focused on the biology of DCs in humans. Using cellular and molecular techniques we are examining the specializations that make DC subsets so adept at detecting inflammatory signals, and driving different modules of acquired immune responses. The role that individual DC subsets provide in directing adaptive immunity is also critical to our understanding human disease, and guides us in identifying new principles and practices that would hopefully lead to new treatments for some of
the challenging human diseases.

Selected Publications:

Visit here for a complete list of our publications

Oulee A. Ma F., Teles RMB., de Andrade Silva BJ., Pellegrini M., Klechevsky E., Harman AN., Rhodes JW., Modlin RL. Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells (2021) Front Immunol.; 12:695373. PMID: 34512625; PubMed Central PMCID: PMC8426439.

Korenfeld, D., Gorvel, L., Munk, A., Man, J., Schaffer, A., Tung, T., Mann, C., Klechevsky, E. A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease. (2017) JCI Insight. Sep 21;2(18). PMCID: PMC5621884

Artyomov, M.N.*, Munk, A.*, Gorvel, L., Korenfeld, D., Cella, M., Tung, T., Klechevsky, E. (2015) Modular expression analysis reveals functional conservation between human Langerhans Cells and mouse cross-priming dendritic cells. J Exp Med. May 4;212(5):743-57. PMCID PMC4419344 *equal contributors
Human dendritic cells - stars in the skin.Klechevsky E. Eur J Immunol. 2013

Banchereau J, Zurawski S, Thompson-Snipes L, Blanck JP, Clayton S, Munk A, Cao Y, Wang Z, Khandelwal S, Hu J, McCoy WH 4th, Palucka KA, Reiter Y, Fremont DH, Zurawski G, Colonna M, Shaw AS, Klechevsky E. Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci U S A. 2012 Oct 29.

Banchereau J, Thompson-Snipes L, Zurawski S, Blanck JP, Cao Y, Clayton S, Gorvel JP, Zurawski G, Klechevsky E. The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming.Blood. 2012 Jun 14;119(24):5742-9.

Klechevsky E, Liu M, Morita R, Banchereau R, Thompson-Snipes L, Palucka AK, Ueno H, Banchereau J. Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines. Hum Immunol. 2009 May;70(5):281-8.

Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes L, Briere F, Chaussabel D, Zurawski G, Palucka AK, Reiter Y, Banchereau J, Ueno H. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity. 2008 Sep 19;29(3):497-510.

Last Updated: 11/29/2022 2:41:22 PM

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