Nima Mosammaparast, M.D., Ph.D.

Assistant Professor
Pathology and Immunology

Molecular Cell Biology Program
Molecular Genetics and Genomics Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-747-5472

  • 314-747-5476

  • 8118

  • mosammaparast@WUSTL.EDU

  • https://wupathlabs.wustl.edu/mosammaparast/

  • DNA, repair, signaling, chromatin, cancer

  • Understanding the molecular mechanisms of the DNA damage response and DNA repair in human cells

Research Abstract:

The human genome is constantly under assault from endogenous and exogenous forms of damage and needs to be repaired to maintain cell viability and prevent oncogenesis. At the same time, DNA damaging agents are used for cancer therapy. Therefore understanding DNA repair is important for both the prevention of cancer as well as its treatment. How do human cells sense DNA damage and activate repair? Are these processes altered in specific disease states? How does the cell promote DNA repair in the context of chromatin and different stages of the cell cycle?
We are broadly interested in understanding DNA repair mechanisms and signaling in human cells, and how these processes may be altered in tumors. Our lab uses a variety of biochemical, cell biological, and animal model systems to answer these questions. Ultimately, we hope to apply the knowledge that we gain to improve diagnostic and therapeutic outcomes for cancer.

Selected Publications:

Zhao Y, Mudge MC, Soll JM, Rodrigues RB, Byrum AK, Schwarzkopf EA, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N. (2018) OTUD4 is a phospho-activated K63-deubiquitinase that regulates MyD88-dependent signaling.
Molecular Cell, 69:505-516.

Brickner JB, Soll JM, Lombardi PM, Vagbo CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gecz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. (2017) "A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair."
Nature, 551:389-393.

Lemacon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou Mosammaparast N, Vindigni A. (2017) MRE11 and EXO1 nucleases degrade reversed forks and lead to MUS81-dependent fork rescue in BRCA2-deficient cells.
Nature Communications, 8:860.

Soll JM, Sobol RW, Mosammaparast N. (2017) “Regulation of DNA alkylation damage repair: lessons and therapeutic opportunities.”
Trends Biochem Sci, 42:106-218.

Zhao Y, Majid MC, Soll JM, Brickner JR, Dango S, Mosammaparast N. (2015) “Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.”
EMBO Journal. 34:1687-703.

Zhao Y, Brickner JR, Majid MC, Mosammaparast N. (2014) “Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair.”
Trends in Cell Biology. 24:426-434.

Last Updated: 6/21/2018 11:44:11 AM

Common methylation marks on histones H3 and H4 and their various functions described to date. (From Mosammaparast and Shi, Annual Rev. Biochem, 2010)
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