Nima Mosammaparast, M.D., Ph.D.

Assistant Professor
Pathology and Immunology

Molecular Cell Biology Program
Molecular Genetics and Genomics Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-747-5472

  • 314-747-5476

  • 8118

  • mosammaparast@WUSTL.EDU


  • DNA, repair, signaling, chromatin, cancer

  • Understanding the molecular mechanisms of the DNA damage response and DNA repair in human cells

Research Abstract:

The human genome is constantly under assault from endogenous and exogenous forms of damage and needs to be repaired to maintain cell viability and prevent oncogenesis. At the same time, DNA damaging agents are used for cancer therapy. Therefore understanding DNA repair is important for both the prevention of cancer as well as its treatment. How do human cells sense DNA damage and activate repair? Are these processes altered in specific disease states? How does the cell promote DNA repair in the context of chromatin and different stages of the cell cycle?
We are broadly interested in understanding DNA repair mechanisms and signaling in human cells, and how these processes may be altered in tumors. Our lab uses a variety of biochemical, cell biological, and animal model systems to answer these questions. Ultimately, we hope to apply the knowledge that we gain to improve diagnostic and therapeutic outcomes for cancer.

Selected Publications:

Soll JM, Sobol RW, Mosammaparast N. (2016) “Regulation of DNA alkylation damage repair: lessons and therapeutic opportunities.” (submitted)

Brickner JR, Lombardi PM, Soll JM, Mudge MC, Jackson J, Blazosky E, Byrum AK, Zhao Y, Vindigni A, Wolberger C, Mosammaparast N. (2016) “The ASCC complex mediates a ubiquitin-dependent signaling axis specific for alkylation damage repair.” (submitted)

Zhao Y, Majid MC, Soll JM, Brickner JR, Dango S, Mosammaparast N. (2015) “Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.” EMBO Journal. 34:1687-703.

Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP. (2014) “KAP-1 promotes resection of broken DNA ends not protected by H2A.X and 53BP1 in G1-phase lymphocytes.” Molecular and Cellular Biology. 34:2811-21.

Zhao Y, Brickner JR, Majid MC, Mosammaparast N. (2014) “Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair.” Trends in Cell Biology. 24:426-434.

Mosammaparast N*, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner BA, Shi Y*. (2013) “The histone demethylase LSD1/KDM1A promotes the DNA damage response.”
(*corresponding authors) Journal of Cell Biology. 203:457-70.

Dango S*, Mosammaparast N*, Sowa ME, Wu F, Xiong LJ, Park K, Rubin M, Gygi SP, Harper JW, Shi Y. (2011) “DNA unwinding by ASCC3 helicase is coupled to ALKBH3 dependent DNA alkylation repair and cancer cell proliferation.”
(*equal contribution) Molecular Cell. 44:373-84.
Previewed in: “Unraveling a connection between DNA demethylation repair and cancer.” Molecular Cell 44:343-4. [PubMed]

Last Updated: 8/19/2016 4:16:42 PM

Common methylation marks on histones H3 and H4 and their various functions described to date. (From Mosammaparast and Shi, Annual Rev. Biochem, 2010)
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