Jonathan R. Silva, Ph.D.
Associate Professor
Biomedical Engineering
Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program
Computational and Systems Biology Program
314-935-8837
314-935-9553
314-935-7448
1097
Whitaker Hall 235
jonsilva@wustl.edu
http://silvalab.bme.wustl.edu/
Bioelectricity, Arrhythmias, Modeling, Molecular Imaging, Electrophysiology, Induced Pluripotent Stem Cells
Engineering to help cardiac arrhythmia patients feel better and live longer.
Research Abstract:
We want to help patients who are suffering from arrhythmia feel better and live longer. Current anti-arrhythmic drug therapies are effective for some patients and not for others. Our lab leverages insight from cutting-edge molecular imaging, induced pluripotent stem cell models, and computational inference to develop novel and personalized approaches for arrhythmia therapy.
Selected Publications:
Zhu, W., Voelker, T. L., Moreno, J. D., Mazzanti, A., Priori, S. G., & Silva, J. R. (2018). Molecular Basis of Mexiletine Response Variability in Sodium Channels with Long QT Mutations. Biophysical Journal, 114(3), 636a.
Moreno, J., Zhu, W., & Silva, J. (2018). A Computational Model of the Cardiac Sodium Channel DIII Voltage Sensor: Connecting Molecular Movements to Tissue Dynamics. Biophysical Journal, 114(3), 632a-633a.
Silva, J. R. (2018). How to connect cardiac excitation to the atomic interactions of ion channels. Biophysical journal, 114(2), 259-266.
Zhu, W., Voelker, T. L., Varga, Z., Schubert, A. R., Nerbonne, J. M., & Silva, J. R. (2017). Mechanisms of noncovalent β subunit regulation of NaV channel gating. The Journal of general physiology, jgp-201711802.
Last Updated: 7/27/2018 11:23:20 AM
Using induced pluripotent stem cells to model drug block of potassium channels. The simulated electrocardiogram is measured with a multi-electrode array.