Jonathan R. Silva, Ph.D.

Assistant Professor
Biomedical Engineering

Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program
Computational and Systems Biology Program

  • 314-935-8837

  • 314-935-9553

  • 314-935-7448

  • 1097

  • Whitaker Hall 235

  • jonsilva@wustl.edu

  • http://silvalab.bme.wustl.edu/

  • Cardiac, Bioelectricity, Ion Channel, Sodium Channel, Action Potential, Modeling, Electrophysiology, Voltage Clamp Fluorometry

  • Predicting how changes in ion channel nano-conformations affect cell and organ electrophysiology

Research Abstract:

Neuronal and myocyte bioelectricity arises from the atomic interactions of ion channels. While the atoms and molecules that form channels interact at nanometer and nanosecond time-scales, heart beats and neuronal signals travel over centimeters and seconds. Bridging these time and length scales is a primary barrier to developing useful small molecules therapies. To gain a multiscale understanding, we use computational models that are based on data we collect with cutting-edge biophysics methods.

Selected Publications:

Varga, Z., Zhu, W., Schubert, A. R., Pardieck, J. L., Krumholz, A., Hsu, E. J., ... & Silva, J. R. (2015). Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation: Arrhythmia and Electrophysiology, CIRCEP-115. PMID: 26283144

Silva, J.R. & Rudy, Y. (2010). Multi-scale electrophysiology modeling: from atom to organ. Journal of General Physiology 135 (6), 575. PMID: 20513759.

Silva, J.R., et al (2009). A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proceedings of the National Academy of Sciences, 106(27), 11102-11106. PMID: 19549851.

Last Updated: 9/22/2015 10:34:25 AM

Schematic of the voltage clamp fluorometry protocol.
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