Eli Roberson, Ph.D.

Assistant Professor
Internal Medicine
Rheumatology
Genetics

Human and Statistical Genetics Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • 314 362-9736

  • 314-514-3634

  • 8045

  • CSRB 10008

  • eroberson@WUSTL.EDU

  • https://www.robersonlab.org

  • human genetics; autoimmune; inflammatory disease; biomarkers; high-throughput sequencing; precision medicine

  • Using bench molecular biology, high-throughput sequencing, and bioinformatics to understand human inflammatory / autoimmune disease.

Research Abstract:

Our lab is focused on understanding the genetics and molecular biology of autoimmune and inflammatory diseases. While these diseases are collectively relatively common, targeted treatment for many of the individual conditions is limited due to a lack of understanding of the events that trigger disease and poor molecular biomarkers of disease activity. General immunosuppression is effective for some, but others have progressive disease regardless of standard therapy. We use human tissue samples with high-throughput biology and bioinformatics to fill in these knowledge gaps.

We currently have projects involving hidradenitis suppurativa, dermatomyositis, systemic sclerosis, and rheumatoid arthritis. We work closely with the clinicians in our division and at other universities to identify patients relevant to these studies that could contribute low-risk biological samples of disease-affected tissue.

Importantly, we combine the environment of a traditional wet-bench molecular biology lab with high-throughput sequencing and computational approaches. We both generate large amounts of data and analyze it. We also use this experience to develop new molecular techniques and build the software necessary to understand it. The broad range of potential projects and training focuses makes the lab a unique training environment.

Selected Publications:

† = equal contribution.

Roberson EDO (2018). Motif Scraper: a cross-platform, open-source tool for identifying degenerate nucleotide motif matches in FASTA files. Bioinformatics, bty437. PMID: 29850891.

Varga J & Roberson EDO (2015). Editorial: genomic advances in systemic sclerosis: it is time for precision. Arthritis Rheum 67(11): 2801-5. PMID: 26239971.

Roberson EDO. Identification of high-efficiency 3’GG gRNA motifs in indexed FASTA files with ngg2 (2015). PeerJ Comput Sci, 1:e33. PMCID: PMC4750479.

Triebwasser MP†, Roberson EDO†, Yu Y, Schramm EC, Raychaudhuri S, Seddon JM, Atkinson JP (2015). Rare variants in the functional domains of Complement Factor H are associated with age-related macular degeneration. Invest Opthalmol Vis Sci, 56(11):6873-6878. PMCID: PMC4627248.

Jordan CT, Cao L, Roberson EDO, Pierson KC, Yang C-F, Joyce CE, Ryan C, Duan S, Helms CA, Liu Y, Chen Y, McBride AA, Hwu W-L, Wu J-Y, Chen Y-T, Menter A, Goldbach-Mansky R, Lowes MA, Bowcock AM (2012). PSORS2 is due to mutations in CARD14. Am J Hum Genet, 90(5): 784-795. PMCID: PMC3376640.

Roberson EDO†, Liu Y†, Ryan C, Joyce CE, Duan S, Cao L, Martin A, Liao W, Menter A, Bowcock AM (2011). A subset of methylated CpG sites differentiate psoratic from normal skin. J Invest Dermatol, 132(3 Pt 1): 583-592. PMCID: PMC3568942.

Roberson EDO, Wohler ES, Hoover-Fong JE, Lisi E, Stevens EL, Thomas GH, Leonard J, Hamosh A, Pevsner J (2011). Genomic analysis of partial 21q monosomies with variable phenotypes. Eur J Hum Genet 19(2): 235-8. PMCID: PMC3025784.

Harbour JW, Onken MD, Roberson EDO, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM (2010). Frequent mutations of BAP1 in metastasizing uveal melanomas. Science, 330(6009): 1410-1413. PMCID: PMC3087380.

Roberson EDO & Pevsner JA (2009). Visualization of shared genomic regions and meiotic recombination in high-density SNP data. PLOS ONE, 4(8): e6711. PMCID: PMC2725774.

Last Updated: 8/23/2018 12:51:34 PM

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