Stephanie A. Fritz, M.D., MSCI

Associatet Professor
Pediatrics
Infectious Diseases

Human and Statistical Genetics Program

  • 314-454-4115

  • 8116

  • MPRB, 6th Floor, Entry 4 and Northwest Tower 10th Floor

  • fritz.s@wustl.edu

  • http://research.peds.wustl.edu/labs/fritz_stephanie/Home

  • Staphylococcus aureus; antibiotic resistance; epidemiology; infection treatment and prevention; genomic determinants of disease; host immune response

  • Asking and answering critical questions to guide clinical practice and ameliorate childhood suffering due to staphylococcal disease

Research Abstract:

I lead a multidisciplinary, clinical and translational research team focusing on Staphylococcus aureus, an aggressive pathogen causing a wide array of human disease. As I began my clinical Pediatric Infectious Diseases fellowship, it was quickly evident that community-associated methicillin-resistant S. aureus (CA-MRSA) infections in healthy children were emerging as a major public health challenge. Skin and soft tissue infections (SSTIs) comprise the majority of burden posed by CA-MRSA, resulting in lost time from school and work, pain, and subsequent scarring. Patients with invasive, life-threatening CA-MRSA infections underscore the severity of this problem, and inspire me to combat this scourge. Caring for these patients, I identified important deficits in our knowledge of CA-MRSA colonization and disease, treatment and prevention, microbial virulence mechanisms, and host defenses. To confront this major public health problem, I have developed an integrated research platform to define the clinical and molecular epidemiology of S. aureus colonization and infection, determine the effectiveness of strategies for treating and preventing S. aureus infections, and specify the bacterial and host mechanisms driving S. aureus transmission and disease.

Selected Publications:

Fritz SA, Hogan PG, Hayek G, Eisenstein KA, Rodriguez M, Epplin EK, Garbutt J, Fraser VJ. Household versus individual approaches to eradication of community-associated Staphylococcus aureus in children: a randomized trial. Clin Infect Dis 2012; 54:743-751. PMCID: PMC3284213.

Fritz SA, Tiemann KM, Hogan PG, Epplin EK, Rodriguez M, Al-Zubeidi DN, Bubeck Wardenburg J, Hunstad DA. A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection. Clin Infect Dis 2013; 56:1554-1561. PMCID: PMC3641868.

Rodriguez M, Hogan PG, Burnham CD, and Fritz SA. Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S. aureus skin and soft tissue infections. J Pediatr 2014; 164:105-111. PMCID: PMC3921902.

Fritz SA, Hogan PG, Singh LN, Thompson RM, Wallace MA, Whitney K, Al-Zubeidi D, Burnham CD, Fraser VJ. Staphylococcus aureus contamination of environmental surfaces in households with children infected with methicillin-resistant S. aureus. JAMA Pediatr 2014; 168:1030-1038. PMCID: PMC4219733.

Rodriguez M, Hogan PG, Burnham CD, Fritz SA. Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S. aureus skin and soft tissue infections. J Pediatr 2014; 164:105-111. PMCID: PMC3921902.

Rodriguez M, Hogan PG, Satola SW, Crispell E, Wylie T, Gao H, Sodergren E, Weinstock GM, Burnham CD, Fritz SA. Discriminatory indices of typing methods for epidemiologic analysis of contemporary Staphylococcus aureus strains. Medicine 2015; 94:e1534. PMCID: PMC4635816.

Wang JW, Hogan PG, Hunstad DA, Fritz SA. Vitamin D sufficiency and Staphylococcus aureus infection in children. Pediatr Infect Dis J 2015; 34:544-545. PMCID: PMC4400212.

Reich PJ, Boyle MG, Hogan PG, Johnson AJ, Wallace MA, Elward AM, Warner BB, Burnham CD, Fritz SA. Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge. Clin Microbiol Infect 2016;22:645.e1-8. PMCID: PMC4987169.

Burnham CA, Hogan PG, Wallace MA, Deych E, Shannon W, Warren DK, Fritz SA. Topical decolonization does not eradicate the skin microbiota of community-dwelling or hospitalized adults. Antimicrob Agents Chemother 2016; 60:7303-7312. PMCID: PMC5119011.

Daum RS, Miller LG, Immergluck L, Fritz S, Creech CB, Young D, Kumar N, Downing M, Pettibone S, Hoagland R, Eells SJ, Boyle MG, Parker TC, Chambers HF. A placebo-controlled trial of antibiotics for smaller skin abscesses. New Engl J Med 2017; 376:2545-2555. PMID: 28657870.

Last Updated: 8/21/2017 8:55:04 AM

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