Amit Pathak, Ph.D.

Assistant Professor
Mechanical Engineering & Materials Science

Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314 935-7585

  • 314 935-4014

  • 1185

  • Urbauer Hall, Room 307

  • pathaka@WUSTL.EDU

  • pathaklab.wustl.edu

  • @Pathak_Lab

  • Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;

  • We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.

Research Abstract:

Professor Pathak`s research interests include mechanobiology of the cell, biomaterials, and interactions between cells and extracellular matrices. In particular, his research aims to understand how numerous parameters that define three-dimensional ECMs (e.g. stiffness, porosity, and fibrous microstructure) all interactively affect cell motility through a variety of sub-cellular mechanisms. His lab tackles this multi-variable problem through a multidisciplinary approach that includes fabrication of new matrix platforms, development of advanced measurement tools in cell biology, and construction of predictive computational models. Within this scheme, his current research program is organized around these broad topics:

Regulation of tumor cell invasion by matrix properties

Mechanical memory in cell migration

Epithelial cells in confined and heterogeneous environments

Single cell migration in mechanically diverse environments

Selected Publications:

S Nasrollahi, C Walter, AJ Loza, GV Schimizzi, GD Longmore, and A Pathak (2017). Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials, 146, pg. 146-155.

C Walter§, L Crawford§, M Lai, JA Toonen, Y Yuan, S Sakiyama-Elbert, DH Gutmann, A Pathak (2017), Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma. Biophysical Journal, 112, 1535-1538.

S Nasrollahi, S Banerjee, B Qayum, P Banerjee, A Pathak (2016). Nano-scale matrix topography influences micro-scale cell motility through adhesions, actin organization, and cell shape. ACS Biomaterials Science & Engineering. 3(11), pp 2980–2986.

A Pathak (2016), Scattering of Cell Clusters in Confinement. Biophysical Journal, 111(7), 1496-1506.

S Nasrollahi and A Pathak (2016), Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices, Scientific Reports, 9, 18831.

A Pathak and S Kumar (2013). Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integrative Biology, 5(8), 1067-75.

A Pathak and S Kumar (2011). From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices. PLoS ONE, 6(3): e18423.

A Pathak and S Kumar (2012). Independent regulation of tumor cell migration by matrix stiffness and confinement. Proceedings of the National Academy of Sciences USA, 109(26), 10334-10339.

A Pathak, RM McMeeking, AG Evans and VS Deshpande (2011). An analysis of the co-operative mechano-sensitive feedback between intracellular signaling, focal adhesion development and stress fiber contractility. Journal of Applied Mechanics, 78(4), 041001-11.

A Pathak, VS Deshpande, RM McMeeking and AG Evans (2008). The simulation of stress fibre and focal adhesion development in cells on patterned substrates. Journal of the Royal Society Interface, 5, 507-524.

Last Updated: 8/2/2018 2:24:30 PM

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