Amit Pathak, Ph.D.

Assistant Professor
Mechanical Engineering & Materials Science

Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314 935-7585

  • 314 935-4014

  • 1185

  • Jolley Hall, Room 207

  • pathaka@WUSTL.EDU


  • Biomechanics, biomaterials, mechanobiology of the cell, and interactions between cells and extracellular matrices

Research Abstract:

Professor Pathak's research interests include biomechanics, biomaterials, mechanobiology of the cell, and interactions between cells and extracellular matrices. In particular, his research aims to understand how numerous parameters that define three-dimensional ECMs (e.g. stiffness, porosity, and fibrous microstructure) all interactively affect cell motility through a variety of sub-cellular mechanisms. His lab tackles this multi-variable problem through a multidisciplinary approach that includes fabrication of new matrix platforms, development of advanced measurement tools in cell biology, and construction of predictive computational models.

Selected Publications:

Pathak, A and S Kumar (2013). Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integrative Biology, Vol. 5(8), 1067-75.

Pathak, A and S Kumar (2012). Independent regulation of tumor cell migration by matrix stiffness and confinement. Proceedings of the National Academy of Sciences USA, Vol. 109(26), 10334-10339.

Pathak, A and S Kumar (2011) From molecular signal activation to locomotion: an integrated, multiscale analysis of cell motility on defined matrices. PLoS ONE 6(3):e18423.

Pathak, A, RM McMeeking, AG Evans and VS Deshpande, (2010) An analysis of the co-operative mechano-sensitive feedback between intracellular signaling, focal adhesion development and stress fiber contractility. Journal of Applied Mechanics 78(4):041001-12.

Pathak, A, VS Deshpande, RM McMeeking and AG Evans (2008) The simulation of stress fibre and focal adhesion development in cells on patterned substrates. Journal of the Royal Society Interface 5(22):507-524.

Last Updated: 12/15/2014 11:06:14 AM

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