Simon Tang, Ph.D.

Assistant Professor
Orthopaedic Surgery

Biochemistry, Biophysics, and Structural Biology Program

  • 314 286-2664

  • 8233

  • tangs@wustl.edu

  • Understanding the biological regulation of skeletal matrix quality

Research Abstract:

With the overall theme of understanding the biological regulation of skeletal matrix quality, our research group integrates engineering and biology approaches for (1) understanding the effect of disease mechanisms on the structure-function relationships of skeletal tissues and (2) developing of translatable therapeutic and regenerative strategies for these diseases. The investigation of these scientific questions includes the application of finite element analyses, multiscale tissue mechanics, and the functional imaging of skeletal tissues for regenerative medicine with in vitro and in vivo biological systems.

Selected Publications:

A novel technique for the contrast-enhanced microCT imaging of murine intervertebral discs.
Lin KH, Wu Q, Leib DJ, Tang SY.
Journal of the mechanical behavior of biomedical materials. 2016; 63:66-74.

Microstructural and compositional contributions towards the mechanical behavior of aging human bone measured by cyclic and impact reference point indentation.
Abraham AC, Agarwalla A, Yadavalli A, Liu JY, Tang SY.
Bone. 2016; 87:37-43.

A 5 nW Quasi-Linear CMOS Hot-Electron Injector for Self-Powered Monitoring of Biomechanical Strain Variations.
Zhou L, Abraham AC, Tang SY, Chakrabartty S.
IEEE transactions on biomedical circuits and systems. 2016;

Intrinsic mechanical behavior of femoral cortical bone in young, osteoporotic and bisphosphonate-treated individuals in low- and high energy fracture conditions.
Zimmermann EA, Schaible E, Gludovatz B, Schmidt FN, Riedel C, Krause M, Vettorazzi E, Acevedo C, Hahn M, Püschel K, Tang S, Amling M, Ritchie RO, Busse B.
Scientific reports. 2016; 6:21072.

Multiscale Predictors of Femoral Neck In Situ Strength in Aging Women: Contributions of BMD, Cortical Porosity, Reference Point Indentation, and Nonenzymatic Glycation.
Abraham AC, Agarwalla A, Yadavalli A, McAndrew C, Liu JY, Tang SY.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015; 30(12):2207-14

Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone.
Acevedo C, Bale H, Gludovatz B, Wat A, Tang SY, Wang M, Busse B, Zimmermann EA, Schaible E, Allen MR, Burr DB, Ritchie RO.
Bone. 2015; 81:352-63.

The high-throughput phenotyping of the viscoelastic behavior of whole mouse intervertebral discs using a novel method of dynamic mechanical testing.
Liu JW, Abraham AC, Tang SY.
Journal of biomechanics. 2015; 48(10):2189-94

Zimmermann EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, Busse B, Alliston T, Ager JW 3rd, Ritchie RO. Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14416-21. doi: 10.1073/pnas.1107966108. Epub 2011 Aug 22. Erratum in: Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11890. PubMed PMID: 21873221; PubMed Central PMCID: PMC3167515.

Last Updated: 7/5/2016 9:15:34 AM

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