Irfan J. Lodhi, Ph.D.

Assistant Professor
Internal Medicine
Endocrinology/Metabolism

Molecular Cell Biology Program
Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-747-6766

  • 314-747-6473

  • 314-362-7641

  • 8127

  • 815J Southwest Tower

  • ilodhi@dom.wustl.edu

  • https://www.lodhilab.org

  • Adipose tissue, brown fat, diabetes, obesity, lipogenesis, lipid metabolism, peroxisomes

  • The role of lipid metabolism pathways in the regulation of energy homeostasis.

Research Abstract:

Metabolic disorders, such as diabetes and obesity are major clinical problems with limited treatment options. Our laboratory takes an integrative approach to study the biology of the multifunctional organelles called peroxisomes in the context of these disorders. Peroxisomes are intimately associated with lipid droplets and mitochondria. Their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether-linked phospholipids, may be critical for generating cellular signals required for normal physiology. We have developed several new mouse models to study various aspects of peroxisome biology, including peroxisomal biogenesis, fatty acid oxidation, and ether lipid synthesis. We are interested in the physiological roles of these processes in various metabolic organs, such as adipose tissue, pancreatic islets, liver, and skeletal muscle. The major focus is on the role of peroxisomes in adipose tissue.

Selected Publications:

Lodhi IJ#, Dean JM, He A, Park H, Tan M, Feng C, Song H, Hsu FF, Semenkovich CF (2017). PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Reports 20: 2766–2774. #Corresponding author

Dean JM and Lodhi IJ (2017). Structural and Functional Roles of Ether Lipids. Protein & Cell (ePub ahead of print May 18, 2017).

Cipolla CM and Lodhi IJ (2017). Peroxisomal Dysfunction in Age-Related Diseases. Trends in Endocrinology and Metabolism 28(4): 297-308.

Funai K*, Lodhi IJ*, Spears LD, Yin L, Song H, Klein S, and Semenkovich CF (2016). Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes 65(2):358-70.

Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu F, Link DC, Semenkovich CF (2015). Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability. Cell Metabolism 21(1): 51-64.

Lodhi IJ and Semenkovich CF (2014). Peroxisomes: a Nexus for Lipid Metabolism and Cellular Signaling. Cell Metabolism 19(3): 380-392.

Funai K, Song H, Yin L, Lodhi IJ, Wei X, Yoshino J, Coleman T, and Semenkovich CF (2013) Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. J Clin Invest. 123(3):1229-40. PMCID: PMC3582136

Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, and Semenkovich CF (2012). Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Cell Metabolism 16(2): 189-201. PMCID: PMC3467338

Lodhi IJ, Wei, X and Semenkovich CF (2011). Lipoexpediency: De novo lipogenesis as a metabolic signal transmitter. Trends Endocrinol Metab. 22(1): 1-8. PMCID: PMC3011046

Chakravarthy MV*, Lodhi IJ*, Yin L, Malapaka RV, Xu HE, Turk J and Semenkovich CF (2009). Identification of a Physiologically Relevant Endogenous Ligand for PPARalpha in Liver. Cell 138 (3): 476-488. *Contributed equally. PMCID: PMC2725194


Last Updated: 7/9/2018 7:05:05 PM

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