D.P. Mohapatra, Ph.D.

Associate Professor
Anesthesiology

Neurosciences Program
Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-8229

  • 314-362-8244

  • 314-362-8334

  • 8054

  • 5502-CSRB

  • d.p.mohapatra@wustl.edu

  • http://elysium.wustl.edu/mohapatra_lab/mohapatra_lab/Home.html

  • Pain, Cancer, Translational Pain Biology, Neuronal Excitability, Ion Channels, GPCR, Membrane Biology, Neurophysiology, Cellular Signaling, Neuroprotection, Rodent Behavior, In vivo pharmacology

  • Basic and Translational Pain Biology (Cancer Pain, Neuropathic Pain and Inflammatory Pain)

Research Abstract:

Our research group investigates diverse mechanisms underlying pain pathologies. We extensively utilize rodent models of human diseases/pathologies such as metastatic bone cancer pain, neuropathic pain and inflammatory pain, multidisciplinary approaches to understand the neurobiology of pain, and human tissue analysis and functional assays of human sensory neurons for translational validation of basic science findings in pain. Overall, our goal is to develop and validate new-generation non-opioid drugs for effective management of chronic pain in humans.

Selected Publications:

Shepherd A.J., Mickle A.D., Golden J.P., Mack M.R., Halabi C.M., de Kloet A.D., Samineni V.K., Kim B.S., Krause E.G., Gereau IV R.W., and Mohapatra D.P. (2018). Macrophage angiotensin II type 2 receptor triggers neuropathic pain. Proceedings of the National Academy of Sciences USA [Online early ahead of print]. DOI: https://doi.org/10.1073/pnas.1721815115.

Shepherd A.J., Copits B., Mickle A.D., Karlsson P., Kadunganattil S., Haroutounian S., Tadinada S.M., de Kloet A.D., Valtcheva M.V., McIlvried L.A., Sheahan T.D., Jain S., Ray P., Usachev Y.M., Dussor G., Krause E.G., Price T.J., Gereau IVth R.W., and Mohapatra D.P. (2018). Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain. Journal of Neuroscience [Online early ahead of print]. DOI: https://doi.org/10.1523/JNEUROSCI.3542-17.2018.

Shepherd A.J., Cloud M.E., Cao Y.-Q., and Mohapatra D.P. (2018). Deficits in burrowing behaviors are associated with mouse models of neuropathic but not inflammatory pain or migraine. Frontiers in Behavioral Neuroscience Vol. 12: 124. doi: 10.3389/fnbeh.2018.00124.

Shepherd A.J.*, Mickle, A.D.*, Kadunganattil S.*, Hu H., and Mohapatra D.P. (2018). Parathyroid hormone-related peptide elicits peripheral TRPV1-dependent mechanical hypersensitivity. Frontiers in Cellular Neuroscience Vol. 12 (article-38): 1-14. *Equal contribution.

Shepherd A.J., and, Mohapatra D.P. (2018). Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice. Neuropharmacology Vol. 130: 18-29.

Gupte R.P., Kadunganattil S., Shepherd A.J., Merrill R.A., Planer W., Bruchas M., Strack S., and Mohapatra D.P. (2016). Convergent Phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology Vol. 101:291-308.

Mickle A.D., Shepherd A.J., Loo L., and Mohapatra D.P. (2015). Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide (PTHrP) through upregulation of TRPV1 function and trafficking. Pain Vol. 156(9): 1620-1636.

Shepherd A.J., Loo L., Gupte R.P., Mickle A.D., and Mohapatra D.P.: Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. Journal of Neuroscience 32(49):17725-17739, 2012.

Loo L., Shepherd A.J., Mickle A.D., Lorca R.A., Shutov L., Usachev Y.M., and Mohapatra D.P.: The C-type natriuretic peptide induces thermal hyperalgesia through a non-canonical Gβγ-dependent modulation of TRPV1 channel. Journal of Neuroscience 32(35):11942-11955, 2012.

Bocksteins E., Labro A.J., Snyders D.J., and Mohapatra D.P. (2012). The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrametic channels. PLoS One. Vol. 7(5): e37143, 2012.

Last Updated: 8/1/2018 9:28:16 AM

Human Dorsal Root Ganglia Tissue Section Showing CGRP-labeled Sensory Neurons and Nerve Fibers (in red)
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