Vivek K. Arora, M.D., Ph.D.

Assistant Professor
Internal Medicine
Oncology

Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program
Immunology Program

  • 314-286-1906

  • 8069

  • arorav@wustl.edu

  • I am physician-scientist with complementary clinical and research interests focused on genitourinary cancer

Research Abstract:

My laboratory is defining genetic determinants of bladder cancer genesis and progression using novel model systems and genomic analysis.

Selected Publications:

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
Halstead AM, Kapadia CD, Bolzenius J, Chu CE, Schriefer A, Wartman LD, Bowman GR, Arora VK.
Elife. 2017 Nov 16;6.

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.
Shah N, Wang P, Wongvipat J, Karthaus WR, Abida W, Armenia J, Rockowitz S, Drier Y, Bernstein BE, Long HW, Freedman ML, Arora VK, Zheng D, SawyersCL.
Elife. 2017 Sep 11;6.

Organoid cultures derived from patients with advanced prostate cancer
Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran L, MacDonald TY, Beltran H, Mosquera JM, Touijer KA, Scardino PT, Laudone VP, Curtis KR, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Solomon SB, Eastham JA, Chi P, Carver B, Rubin MA, Scher HI, Clevers H, Sawyers CL, Chen Y
Cell 2014 Sep 25;159(1):176-87

Aggressive variants of castration-resistant prostate cancer
Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA
Clin Cancer Res 2014 Jun 1;20(11):2846-50

Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, Shah N, Cai L, Efstathiou E, Logothetis C, Zheng D, Sawyers CL
Cell 2013 Dec 5;155(6):1309-22

Androgen receptor signaling regulates DNA repair in prostate cancers
Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL
Cancer Discov 2013 Nov;3(11):1245-53

Overcoming mutation-based resistance to antiandrogens with rational drug design
Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, Chen Y, Greene GL, Shen Y, Sawyers CL
Elife (Cambridge) 2013 Apr 9;2:e00499

Last Updated: 1/25/2018 9:53:03 AM

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