Ying Maggie Chen, M.D., Ph.D.

Assistant Professor
Internal Medicine
Renal

Molecular Genetics and Genomics Program
Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program

  • 8126

  • ychen32@wustl.edu

  • Understanding the molecular mechanisms of primary nephrotic syndrome (NS)

Research Abstract:

We are interested in understanding the molecular mechanisms of primary nephrotic syndrome (NS). All strata of the glomerular capillary wall including glomerular basement membrane (GBM), podocytes and endothelial cells operate in a synchronic and integrated manner to maintain the integrity of the glomerular filtration barrier (GFB).
Defects in GFB may cause proteinuria.

Selected Publications:

Chen Y, Donnelly E, Kobayashi H, DeBusk LM, Lin PC. Gene therapy targeting the Tie2 function
ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum. 52(5)
1585-1594 2005 [Editorial comments]: Pap T and Distler O. Linking angiogenesis to bone
destruction in arthritis. Arthritis Rheum. 52(5) 1346-1348 2005

Chen Y, Kikkawa Y, Miner J. A missense LAMB2 mutation causes congenital nephrotic syndrome by
impairing laminin secretion. J Am Soc Nephrol. 22: 849-858 2011 [Cover illustration] PMC:
PMCID3083307

Chen Y, Marcos LA, Liapis H, Steinberg TH, Morrison AP. An unusual cause of membranous
glomerulonephritis in a patient with HIV. Int Urol Nephrol. 44(3): 983-6 2012 PMID: 21437594

Chen Y, Miner JH. Glomerular basement membrane and related glomerular disease. Translational
Research April 10, 2012 [Epub ahead of print] [Corresponding author, Featured New Investigator
Series] PMCID: PMC3477400

Chen Y, Zhou YF, Go G, Marmerstein JT, Kikkawa Y, Miner J. Laminin β2 gene missense mutation
produces endoplasmic reticulum stress in podocytes. J Am Soc Nephrol. 24: 1223-1233 2013 PMCID:
PMC3736718

Last Updated: 7/22/2015 2:53:44 PM

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