Lori A. Setton, Ph.D.

Professor
Biomedical Engineering
Orthopaedic Surgery
Mechanical Engineering & Materials Science

Developmental, Regenerative and Stem Cell Biology Program
Molecular Cell Biology Program

  • 314 935-7208

  • 314 935-7208

  • 1097

  • setton@wustl.edu

  • Understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus

Research Abstract:

Research in the Laboratory is focused on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus.

Our research employs tools of mechanical engineering, materials synthesis, and cell and molecular biology to advance use of drug depots and biomaterials as therapies for musculoskeletal pathology. Ongoing projects include:

◦Synthesis of novel biomaterials for controlling intervertebral disc cell phenotype and metabolism
◦Progenitor cell differentiation to intervertebral disc cell phenotypes
◦Synthesis of novel drug depots for sustained release of inflammatory antagonists in arthritis and disc pathology
◦Studies of cell-cell and cell-matrix interactions that regulate intervertebral disc and progenitor cell phenotypes
◦Preclinical models of arthritis and intervertebral disc disorders and novel assessments of pain and dysfunction

Selected Publications:

In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.
Bowles RD, Karikari IO, VanDerwerken DN, Sinclair MS, Bell RD, Riebe KJ, Huebner JL, Kraus VB, Sempowski GD, Setton LA.
European journal of pain (London, England). 2016; 20(3):365-76.

Lipid profile of human synovial fluid following intra-articular ankle fracture.
Leimer EM, Pappan KL, Nettles DL, Bell RD, Easley ME, Olson SA, Setton LA, Adams SB.
Journal of orthopaedic research: official publication of the Orthopaedic Research Society. 2016;

Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.
Adams SB, Setton LA, Bell RD, Easley ME, Huebner JL, Stabler T, Kraus VB, Leimer EM, Olson SA, Nettles DL.
Foot & ankle international. 2015; 36(11):1264-71.

Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery.
Mwangi TK, Bowles RD, Tainter DM, Bell RD, Kaplan DL, Setton LA.
International journal of pharmaceutics. 2015; 485(1-2):7-14.

N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc.
Hwang PY, Jing L, Michael KW, Richardson WJ, Chen J, Setton LA.
Cellular and molecular bioengineering. 2015; 8(1):51-62.

Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.
Kimmerling KA, Furman BD, Mangiapani DS, Moverman MA, Sinclair SM, Huebner JL, Chilkoti A, Kraus VB, Setton LA, Guilak F, Olson SA.
European cells & materials. 2015; 29:124-39; discussion 139-40.

Last Updated: 6/30/2016 10:20:29 AM

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