Matthew D. Lew, Ph.D.

Assistant Professor
Electrical & Systems Engineering

Biochemistry, Biophysics, and Structural Biology Program

  • 314-935-6790

  • 314-935-9070

  • 314-935-7500

  • 1042

  • Green Hall 2158



  • in-vivo imaging, 3D super-resolution microscopy, single-molecule fluorescence, computational optics

  • Developing optical tools for biology and medicine

Research Abstract:

The Lew Lab leverages innovations in applied physics, electrical engineering, computational algorithms, and chemistry to create optical imaging systems with unprecedented performance. We partner with scientists and engineers across all disciplines to develop technologies to solve unmet needs in science, medicine, and society.

The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology. Please see our website at for more information

Selected Publications:

1. Liba O, Lew MD, SoRelle ED, Dutta R, Sen D, Moshfeghi DM, Chu S, de la Zerda A. Speckle-modulating optical coherence tomography in living mice and humans. Nature communications. 2017; 8:15845. PMID: 28632205, PMCID: PMC5481831

2. von Diezmann A, Lee MY, Lew MD, Moerner WE. Correcting field-dependent aberrations with nanoscale accuracy in three-dimensional single-molecule
localization microscopy. Optica. 2015; 2(11):985-993. NIHMSID: NIHMS762408, PMID: 26973863, PMCID: PMC4782984

3. Lew MD, Moerner WE. Azimuthal polarization filtering for accurate, precise, and robust single-molecule localization microscopy. Nano letters. 2014; 14(11):6407-13. PMID: 25272093, PMCID: PMC4245985

4. Backlund MP, Lew MD, Backer AS, Sahl SJ, Moerner WE. The role of molecular dipole orientation in single-molecule fluorescence microscopy and implications for
super-resolution imaging. Chemphyschem : a European journal of chemical physics and physical chemistry. 2014; 15(4):587-99. NIHMSID: NIHMS570913,
PMID: 24382708, PMCID: PMC3992256

5. Lew MD, Backlund MP, Moerner WE. Rotational mobility of single molecules affects localization accuracy in super-resolution fluorescence microscopy. Nano letters.
2013; 13(9):3967-72. NIHMSID: NIHMS443666, PMID: 23360306, PMCID: PMC3696529

6. Backer AS, Backlund MP, Lew MD, Moerner WE. Single-molecule orientation measurements with a quadrated pupil. Optics letters. 2013; 38(9):1521-3. NIHMSID:
NIHMS570921, PMID: 23632538, PMCID: PMC3991307

Last Updated: 1/8/2018 10:56:54 AM

Recipient of 2017 NSF CAREER Award
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