Ben Julian Palanca, MD, PhD, MSc

Assistant Professor
Anesthesiology

Neurosciences Program

  • 314 362-7823

  • 314 362-1115

  • 314 747-3977

  • 8054

  • palancab@wustl.edu

  • Anesthesia, delirium, sleep, surgery, electroencephalography, imaging, fMRI, consciousness, cognition, encephalopathy

  • Neural markers that reflect mechanisms of pathological recovery in the postoperative period.

Research Abstract:

My laboratory focuses on the characterization of perioperative neural markers of cognition and consciousness, with the goal of elucidating the mechanisms underlying reversible pathological recovery. The rationale is that interventions during the critical period of perioperative care may 1) enhance patient outcomes and 2) provide insight into underlying neural mechanisms for higher order brain function.

The current scope and rationale of my laboratory include three broad aims:

1) Elucidate the role of preoperative brain function during both sleep and wakefulness and on subsequent recovery in the postoperative period.
2) Characterize the changes in correlated brain activity and cognitive function associated with sleep, sedation, and general anesthesia.
3) Clarify the relationship of early postoperative neural activity and subsequent development and resolution of cognitive dysfunction.

Selected Publications:

Palanca, B.J.A.; Wildes, T.S.; Yu, Y.S.; Ching, S; Avidan MS. (2017). Electroencephalography and delirium in the postoperative period. Br J Anaesth. PMID in Progress.

Kafashan, M.; Ching, S.; Palanca, B.J. (2016). Sevoflurane Alters Spatiotemporal Functional connectivity motifs that link resting-state networks during wakefulness. Front Neural Circuits. Dec 27;10:107. PMID: 28082871; PMCID: PMC5187351

Wildes, T.S.; Winter, A.C.; Maybrier, H.R.; Mickle, A.M.; Lenze, E.J.; Stark, S.; Lin, N.; Inouye, S.K.; Schmitt, E.M.; McKinnon, S.L.; Muench, M.R.; Murphy, M.R.; Upadhyayula, R.T.; Fritz, B.A.; Escallier, K.E.; Apakama, G.P.; Emmert, D.A.; Graetz, T.J.; Stevens, T.W.; Palanca, B.J.; Hueneke, R.L.; Melby, S.; Torres, B.; Leung, J.; Jacobsohn, E.; Avidan, M.S. (2016). Protocol for the electroencephalography guidance of anesthesia to alleviate geriatric syndromes (ENGAGES) study: a pragmatic, randomised clinical trial. BMJ Open. Jun 15; 6(6)e011505. PMID: 27311914; PMCID: PMC4916634.

Palanca, B.J.; Mitra, A.; Larson-Prior, L.; Snyder, A.Z.; Avidan, M.S.; Raichle, M.E. (2015). Resting-state functional magnetic resonance imaging correlates of sevoflurane-induced unconsciousness. Anesthesiology. 2015 Aug; 123(2)346-56.
PMID: 26057259; PMCID: PMC4509973.

Kafashan, M.; Palanca, B.J.; Ching, S. (2014). Bounded-observation Kalman filtering of correlation in multivariate neural recordings. Conf Proc IEEE Eng Med Biol Soc.; 2014:5052-5. PMID: 25571128; PMCID: PMC5296652.

Whitlock, E.L.; Villafranca, A.J.; Lin, N.; Palanca, B.J.; Jacobsohn, E.; Finkel, K.J.; Zhang, L.; Burnside, B.A.; Kaiser, H.A.; Evers, A.S.; Avidan, M.S. (2011). Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology. Dec; 115(6)1209-18. PMID: 22037642; PMCID: PMC3683547.

Avidan, M.S.; Jacobsohn, E.; Glick, D.; Burnside, B.A.; Zhang, L.; Villafranca, A.; Karl, L.; Kamal, S.; Torres, B.; O`Connor, M.; Evers, A.S.; Gradwohl, S.; Lin, N.; Palanca, B.J.; Mashour, G.A. (2011). Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med. Aug 18;365(7):591-600. PMID: 21848460.

Kertai, M.D.; Palanca, B.J.; Pal, N.; Burnside, B.A.; Zhang, L.; Sadiq, F.; Finkel, K.J.; Avidan, M.S. (2011). Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware Trial. Anesthesiology. Mar;114(3):545-56. PMID: 21293252.

Bottros, M.M.; Palanca, B.J.; Mashour, G.A.; Patel, A.; Butler, C.; Taylor, A.; Lin, N.; Avidan, M.S. (2011). Estimation of the bispectral index by anesthesiologists: an inverse turing test. Anesthesiology. May;114(5):1093-101. PMID: 21460704.

Last Updated: 2/16/2017 8:47:26 AM

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