Jonathan Miner, M.D., Ph.D.

Assistant Professor
Internal Medicine
Molecular Microbiology

Immunology Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-747-4439

  • 314-747-4408

  • 8045

  • 10014 CSRB


  • Innate immunity and host-pathogen interactions in autoimmunity.

Research Abstract:

Our lab is studying innate immunity and viral pathogenesis. We also examine ways in which virus-mediated activation of innate immune signaling pathways may trigger autoimmune disease.

Our studies of Zika virus pathogenesis are primarily focused on antiviral immunity in the placenta and developing fetus.

We have generated numerous mouse models of monogenic diseases and are eager to accept additional graduate students to work on these projects.

Selected Publications:

Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ. Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Sci Transl Med. 2018. Jan;426(10), eaao7090.

Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Platt DJ, Yan N, Miner JJ. STING-associated vasculopathy develops independently of IRF3 in mice. J Exp Med. 2017. Sep; epub ahead of print.

Platt DJ and Miner JJ. Consequences of congenital Zika virus infection. Curr Opin Virology. 2017. In press.

Miner JJ, Diamond MS. Zika virus pathogenesis and tissue tropism. Cell Host Microbe. 2017 Feb; 21(2):134-142.

Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE, Lenschow DJ, Diamond MS. Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis. Sci Transl Med. 2017 Feb; 9(375).

Miner JJ, Cao, B, Govero, J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell. 2016. May 19;165(5):1081-91.

Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramge H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 2016. 535(7610):164-8.

Miner JJ, Sene A, Richner JM, Smith AM, Santeford A, Ban N, Weger-Lucarelli J, Manzella F, Rückert C, Govero J, Noguchi KK, Ebel GD, Diamond MS, Apte RS. Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. Cell Rep. 2016 Sep 20;16(12):3208-18.

Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, Diamond MS. A Mouse Model of Zika Virus Pathogenesis. Cell Host & Microbe. 2016. May 11;19(5):720-30.

Miner JJ, Daniels BP, Shrestha B, Proenca-Modena JL, Lew ED, Lazear HM, Gorman MJ, Lemke G, Klein RS, and Diamond MS. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nature Med. 2015 Dec;21(12):1464-72.

Last Updated: 3/14/2018 9:43:31 AM

viSNE plots of splenocytes from WT and STING knockin mice analyzed by CyTOF
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