Andreas Herrlich, M.D., Ph.D.

Associate Professor
Internal Medicine
Nephrology

Molecular Cell Biology Program

  • 314 747-0565

  • 8126

  • aherrlich@wustl.edu

  • Understand the regulation of the release of growth factors and cytokines by metalloproteases cleavage from the cell surface, how it affects communication between different cell types in complex multicellular organs, and its role(s) in pathophysiology.

Research Abstract:

Understand the regulation of the release of growth factors and cytokines by metalloproteases cleavage from the cell surface (ectodomain cleavage), how it affects communication between different cell types in complex multicellular organs, and its role(s) in pathophysiology. As example, epidermal growth factor ligands and tumor necrosis factor alpha are released from pro-ligands by ADAM17 cleavage. We study this process focusing predominantly on different cell types in the kidney and their roles and interactions in injury and repair, but also in tumorstromal cell interactions in cancer. Our primary tools are cell culture techniques, mouse genetics, mouse kidney injury and cancer models, high-resolution imaging and bio-computational analysis.

Selected Publications:

Kefaloyianni E, Muthu LM, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A ADAM17 substrate release in proximal tubule drives kidney fibrosis. JCI Insight 2016

Hartmann M**, Parra LM**, Ruschel A, Schubach S, Li Y, Morrison H, Herrlich A* and Herrlich P* The tumor suppressor NF2 blocks ectodomain cleavage of CD44. Molecular Cancer Research 2015. (*Co-senior authors)

Hartmann M., Parra LM, Ruschel A, Lindner C, Morrison H, Herrlich A* and Herrlich P* Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 [CD44] and of Neuregulin-1 requires Substrate Dimerization.J. Biol. Chem. 2015; PMID 25925953. (*Co-senior authors) JBC Paper of the week July 10, 2015 and JBC Paper of the Year 2015 in the Signal Transduction Category Podcast: https://soundcloud.com/asbmb/substrate-dimerization-regulates-ectodomain-cleavage; Out of JBC papers of the week, only one paper is chosen in each category as a paper of the year.

Parra LM*, Hartmann M*, Schubach S, Li Y, Herrlich P** and Herrlich A** Distinct ICD substrate modifications selectively regulate ectodomain cleavage of NRG1 or CD44. Mol. Cell. Biol. 2015 (** cosenior authorship).

Last Updated: 12/23/2016 11:47:58 AM

Back To Top

Follow us: