Michael Hughes, Ph.D.

Assistant Professor
Internal Medicine
Pulmonary & Critical Care
Genetics

Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Neurosciences Program

  • 314 273-1678

  • 8052

  • michael.hughes@wustl.edu

  • Functional genomics, circadian rhythms, skeletal muscle

  • Our laboratory studies circadian rhythms as a model to better understand how the nervous system regulates behavior and physiology

Research Abstract:

Our laboratory studies circadian rhythms as a model to better understand how the nervous system regulates behavior and physiology. We are especially interested in uncovering the mechanisms driving gene expression rhythms and determining how these molecular oscillations ultimately influence physiological rhythms. We use a combination of approaches, including behavioral neuroscience, molecular biology, genetics, genomics, and bioinformatics.

We also study the functional genomics of muscle using RNA-sequencing. Our recent work shows that thousands of transcripts are differentially expressed among skeletal muscle tissues. Current work in the lab aims to define the transcriptional pathways that establish muscle tissue identity, as well as exploring the role of microRNAs in skeletal muscle specialization.

Selected Publications:

Li, J., Terry, E.E., Fejer, E., Gamba, D., Hartmann, N., Logsdon, J., Michalski, D., Rois, L.E., Scuderi, M.J., Kunst, M., Hughes, M.E. (2016). Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila. Brain, Behavior, and Immunity. doi: 10.1016/j.bbi.2016.11.012.

Wu, G., Anafi, R.C., Hughes, M.E., Kornacker, K., Hogenesch, J.B. (2016). MetaCycle: an integrated R package to evaluate periodicity in large scale data. Bioinformatics. 32 (21), 3351-3353.

Li, J., Grant, G., Hogenesch, J.B., Hughes, M.E. (2015). Considerations for RNA-seq analysis of circadian rhythms. Methods in Enzymology. doi: 10.1016/bs.mie.2014.10.020

Gong, C., Li, C., Qi, X., Song, Z., Wu, J., Hughes, M. E., Li, X. (2015). The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver. Chronobiology International. 32(9): 1254-1263.

Tranel, H.R., Schroder, E.A., England, J., Black, W.S., Bush, H., Hughes, M.E., Esser, K.A. Clasey, J.L., (2015). Physical activity, and not fat mass is a primary predictor of circadian parameters in young men. Chronobiology International. 32(6): 832-841.

Last Updated: 8/2/2017 3:37:09 PM

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