Chao Zhou, Ph.D.

Associate Professor
Biomedical Engineering

Neurosciences Program
Developmental, Regenerative and Stem Cell Biology Program
Cancer Biology Program

  • 315-935-1296

  • 390E Whitaker Hall

  • chaozhou@wustl.edu

  • https://zlab.wustl.edu/

  • Biophotonics, medical instrumentation, imaging sciences, optical coherence tomography (OCT) and microscopy (OCM) and optogenetic pacing

  • Developing novel optical imaging technologies for biomedical applications including cancer research and tissue engineering

Research Abstract:

We are interested in developing novel optical imaging technologies for biomedical applications, especially in developing optical coherence tomography (OCT) and microscopy (OCM) technologies to perform "optical biopsy" and generate 3D in situ images of tissue morphology, function and pathological status in real-time without the need to remove and process specimens.

We are also interested in applying these technologies to a variety of biological and clinical applications, including cancer research, neuroscience, developmental biology and tissue engineering.

Projects include:
Space-division multiplexing optical coherence tomography (SDM-OCT)

Molecular-targeted OCT and OCM for cancer detection

OCT and OCM Imaging in Developmental Biology

3D OCT imaging of Brain Functions

OCT (OCM) combined with deep learning

Optogenetic pacing in Drosophila melanogaster using integrated OCM imaging and red light stimulation system

Selected Publications:

Y.R. Lewis-Israeli, A.H. Wasserman, M.A. Gabalski, B.D. Volmert, Y. Ming, K. A. Ball, W. Yang, J. Zou, G. Ni, N. Pajares, X. Chatzistavrou, W. Li, C. Zhou and A. Aguirre, Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease, Nature Communications, 12, 5142, 2021.


Y. Huang, J. Jerwick, G. Liu, C. Zhou, Full-Range Space-Division Multiplexing Optical Coherence Tomography Angiography, Biomedical Optics Express, 11(8), 4817-4834, 2020.


J. Men, A. Li, J. Jerwick, Z. Li, R. E. Tanzi, C. Zhou, Non-invasive red-light optogenetic control of Drosophila cardiac function, Communications Biology, 3, 336, 2020.


Z. Dong, J. Men, Z. Yang, J. Jerwick, A. Li, R. E. Tanzi, C. Zhou, FlyNet 2.0: Drosophila Heart 3D (2D + time) Segmentation in Optical Coherence Microscopy Images using a Convolutional Long Short-term Memory Neural Network, Biomedical Optics Express, 11(3), 1568-1579, 2020.


J. Jerwick, Y. Huang, Z. Dong, A. Slaudades, A. Brucker, C. Zhou, Wide-field Ophthalmic Space-Division Multiplexing Optical Coherence Tomography, Photonics Research, 8(4), 539-547, 2020.


Z. Dong, G. Liu, G. Ni, J. Jerwick, L. Duan, C. Zhou, Optical coherence tomography image denoising using a generative adversarial network with speckle modulation, Journal of Biophotonics, e201960135, 2020.

Last Updated: 10/8/2021 1:34:54 PM

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