Dennis Goldfarb, Ph.D.

Assistant Professor
Cell Biology and Physiology
Institute for Informatics

Computational and Systems Biology Program

  • d.goldfarb@wustl.edu

  • Computational mass spectrometry, proteomics, and their applications in biology

Research Abstract:

Research in the Goldfarb lab focuses on computational mass spectrometry, proteomics, and their applications in biology. His lab develops open-source solutions for novel data acquisition strategies, data analysis, and visualization tailored to the unique challenges of each experiment. Dr. Goldfarb aims to increase the throughput and reproducibility of large-scale projects with automated pipelines that leverage high-performance computing. Recently his research has concentrated on instrumentation, protein complex identification, and de novo peptide sequencing.

Selected Publications:

Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR.
ACS Chem Biol. 2020 Jan 17;15(1):217-225.

NRF2 Activation in Cancer: From DNA to Protein.
Cloer EW, Goldfarb D, Schrank TP, Weissman BE, Major MB.
Cancer Res. 2019 Mar 1;79(5):889-898. doi: 10.1158/0008-5472.CAN-18-2723. Epub 2019 Feb 13. Review.
PMID: 30760522 Free PMC Article
Similar articles
Select item 30288463

Approximating Isotope Distributions of Biomolecule Fragments.
Goldfarb D, Lafferty MJ, Herring LE, Wang W, Major MB.
ACS Omega. 2018 Sep 30;3(9):11383-11391.

Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.
Cousins EM, Goldfarb D, Yan F, Roques J, Darr D, Johnson GL, Major MB.
Mol Cancer Res. 2018 Feb;16(2):333-344

MSAcquisitionSimulator: data-dependent acquisition simulator for LC-MS shotgun proteomics.
Goldfarb D, Wang W, Major MB.
Bioinformatics. 2016 Apr 15;32(8):1269-71.

Last Updated: 5/11/2020 2:01:38 PM

Back To Top

Follow us: