Vijay K. Samineni, PhD

Assistant Professor

Neurosciences Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • 314 362-8795



  • Visceral Pain, Genomics, Neural Circuits, Emotions

  • Intersection between visceral sensation, organ function, and emotions

Research Abstract:

The central goal of our laboratory is to study common tenets of how visceral organ function is regulated in the brain and how it influences emotional wellbeing. Our lab studies intersection between visceral sensation, organ function, and emotions. We are in pursuit of a comprehensive understanding of how the brain interprets, adapts, and responds to signals from the peripheral organs during normal and pathological states and how it shapes our emotions. We implement genetic, molecular, and neuroanatomical tools to study these questions across the nervous system to link genes, cells, circuits, and behavior.

Mentorship and Commitment to Diversity Statement:
As a mentor, I feel that my job is to show students how exciting science can be while giving them the necessary support to develop practical skills in hypothesis development and experimental design. I strongly believe that diverse groups bring unique skill sets and outlooks to solve problems. I strive for excellence in science we do and believe in creating supportive and inclusive environment regardless of race, background, or beliefs. I want and welcome students and scientists from under-represented and disadvantaged groups to pursue research questions they are passionate about with our group. Being an immigrant myself, I believe in leading a laboratory with a melting pot of passionate researchers with diverse upbringings. I will strive to create an environment that cultivates these beliefs. In my role I will reach out to help individuals that have had to struggle through difficult circumstances, and to provide them with every opportunity to achieve both their personal and professional goals.

Selected Publications:

1. Samineni VK, Grajales-Reyes JG, Grajales-Reyes GE, Tycksen E, Copits BA, Pedersen C, Anukudey ES, Sackey JN, Sewell SB, Bruchas MR, Gereau RW 4th. Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala. Elife. 2021 May 25;10:e68130. doi: 10.7554/eLife.68130.

2. Samineni VK, Grajales-Reyes JG, Sundaram SS, Yoo JJ, Gereau RW 4th. Cell type specific modulation of sensory and affective components of itch in the periaqueductal gray. Nature Communications. Sep 2019. DOI: 10.1038/s41467-019-12316-0.

3. Mickle AD, Won SM, Noh KN, Yoon J, Meacham KM, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Gereau RW 4th, Rogers JA. A soft, wireless closed-loop neuromodulation system for treating bladder dysfunction. Nature. Jan 2019. doi: 10.1038/s41586-018-0823-6.

4. Hibberd TJ, Feng J, Lou J, Yang P, Samineni VK, Gereau RW 4th, Spencer NJ, Hu H. Optogenetic control of the enteric nervous system and induction of colonic motility generating increased transit of luminal content. Gastroenterology. Aug 2018 doi: 10.1053/j.gastro.2018.05.029.

5. DeBerry JJ*, Samineni VK*, Copits BA, Sullivan CJ, Vogt SK, Albers KM, Davis BM, Gereau RW 4th. Differential Regulation of Bladder Pain and Voiding Function by Sensory Afferent Populations Revealed by Selective Optogenetic Activation. Front. Integr. Neurosci., Feb 2018 *co-first author

Last Updated: 12/27/2022 3:16:12 PM

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