Dineo Khabele, M.D.

Mitchell & Elaine Yanow Professor & Chair
Obstetrics and Gynecology

Cancer Biology Program
Molecular Genetics and Genomics Program
Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-7139

  • khabeled@wustl.edu

  • clinical and translational research in gynecologic oncology, with a focus on ovarian cancer

Research Abstract:

Dineo Khabele, MD is the Mitchell & Elaine Yanow Professor and Chair of the Department of Obstetrics & Gynecology at Washington University School of Medicine in St. Louis. She is a recognized physician-scientist with extensive clinical and translational research experience in gynecologic oncology, with a focus on ovarian cancer. Dr. Khabele’s ovarian cancer research is funded by the National Institutes of Health (NIH)/National Cancer Institute (NCI). Her ovarian cancer research interests include chemotherapy resistance, DNA repair, epigenetic targets for therapy, and targeting the tumor microenvironment. She is a dedicated educator and mentor to students, residents, fellows, and faculty. She is an advocate for women’s health, women’s cancers, and health equity.

Selected Publications:

Homologous recombination deficiency real-time clinical assays, ready or not?
Fuh K, Mullen M, Blachut B, Stover E, Konstantinopoulos P, Liu J, Matulonis U, Khabele D, Mosammaparast N, Vindigni A.
Gynecol Oncol. 2020 Dec;159(3):877-886. doi: 10.1016/j.ygyno.2020.08.035. Epub 2020 Sep 20.

A Perspective on James Marion Sims, MD, and Antiblack Racism in Obstetrics and Gynecology.
Khabele D, Holcomb K, Connors NK, Bradley L.
J Minim Invasive Gynecol. 2021 Feb;28(2):153-155. doi: 10.1016/j.jmig.2020.10.027. Epub 2020 Nov 6.

Expression of p52, a non-canonical NF-kappaB transcription factor, is associated with poor ovarian cancer prognosis.
Hufnagel DH, Wilson AJ, Saxon J, Blackwell TS, Watkins J, Khabele D, Crispens MA, Yull FE, Beeghly-Fadiel A.
Biomark Res. 2020 Sep 15;8:45. doi: 10.1186/s40364-020-00227-y. eCollection 2020.

The Role of Race and Gender in the Career Experiences of Black/African-American Academic Surgeons: A Survey of the Society of Black Academic Surgeons and a Call to Action.
Crown A, Berry C, Khabele D, Fayanju OM, Cobb A, Backhus L, Smith R, Sweeting R, Hasson R, Johnson-Mann C, Oseni T, Newman EA, Turner P, Karpeh M, Pugh C, Jordan AH, Henry-Tillman R, Joseph KA.
Ann Surg. 2020 Sep 15. doi: 10.1097/SLA.0000000000004502. Online ahead of print.

Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.
Hoover AA, Hufnagel DH, Harris W, Bullock K, Glass EB, Liu E, Barham W, Crispens MA, Khabele D, Giorgio TD, Wilson AJ, Yull FE.
BMC Cancer. 2020 Oct 7;20(1):970. doi: 10.1186/s12885-020-07450-8.
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