Michael Meers, PhD

Assistant Professor
Genetics

Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Cancer Biology Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-747-4061

  • MSC 8232-0041-05

  • 5110 Couch Biomedical Research Building

  • meers@wustl.edu

  • http://genetics.wustl.edu/meerslab

  • https://twitter.com/mpmeers

  • Chromatin, Transcription Factors, Epigenomics, Cell fate, Single-cell

  • Understanding the molecular determinants of cellular diversity

Research Abstract:

Trillions of cells in the human body adopt thousands of different fates based on their underlying gene regulatory networks. We study how those networks are physically specified at the molecular level via three major themes:

--We study the interface between transcription factors and the chromatin landscape they encounter.

--We develop genomics techniques to observe cell-specific chromatin landscapes at high resolution.

--We apply new techniques and molecular paradigms to better understand how transcription factor-chromatin interactions play roles in disease.


Specific applications of our work include:

--Understanding how pioneer transcription factors overcome chromatin barriers to initiate developmental transitions

--Developing multifactorial single-cell epigenome profiling approaches to understand how distinct chromatin-associated proteins interact with each other in genomic space during cell differentiation

--Using epigenome profiling to identify common principles of chromatin dysregulation that occur in cancers as diverse as pediatric glioma and mixed-lineage leukemia

Selected Publications:

Multifactorial profiling of epigenetic landscapes at single-cell resolution using MulTI-Tag.
Meers MP, Llagas G, Janssens DH, Codomo CA, Henikoff S.
Nat. Biotech. doi: 10.1038/s41587-022-01522-9. Epub 2022 Oct 31.

CUT&Tag2for1: a modified method for simultaneous profiling of the accessible and silenced regulome in single cells.
Janssens DH, Otto DJ, Meers MP, Setty M, Ahmad K, Henikoff S.
Genome Biol. 2022 Mar 17;23(1):81. doi: 10.1186/s13059-022-02642-w.

Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia.
Janssens DH, Meers MP, Wu SJ, Babaeva E, Meshinchi S, Sarthy JF, Ahmad K, Henikoff S.
Nat Genet. 2021 Nov;53(11):1586-1596. doi: 10.1038/s41588-021-00941-9. Epub 2021 Oct 18.

Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth.
Nyquist MD, Ang LS, Corella A, Coleman IM, Meers MP, Christiani AJ, Pierce C, Janssens DH, Meade HE, Bose A, Brady L, Howard T, De Sarkar N, Frank SB, Dumpit RF, Dalton JT, Corey E, Plymate SR, Haffner MC, Mostaghel EA, Nelson PS.
J Clin Invest. 2021 Jun 15;131(12):e151719. doi: 10.1172/JCI151719.

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.
Sarthy JF, Meers MP, Janssens DH, Henikoff JG, Feldman H, Paddison PJ, Lockwood CM, Vitanza NA, Olson JM, Ahmad K, Henikoff S.
Elife. 2020 Sep 9;9:e61090. doi: 10.7554/eLife.61090.

MYCN amplification and ATRX mutations are incompatible in neuroblastoma.
Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, Zhou X, Jeon J, Griffiths L, Nguyen R, Norrie J, Easton J, Mulder H, Yergeau D, Liu Y, Wu J, Van Ryn C, Naranjo A, Hogarty MD, Kamiński MM, Valentine M, Pruett-Miller SM, Pappo A, Zhang J, Clay MR, Bahrami A, Vogel P, Lee S, Shelat A, Sarthy JF, Meers MP, George RE, Mardis ER, Wilson RK, Henikoff S, Downing JR, Dyer MA.
Nat Commun. 2020 Feb 14;11(1):913. doi: 10.1038/s41467-020-14682-6.

Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded.
Meers MP, Janssens DH, Henikoff S.
Mol Cell. 2019 Aug 8;75(3):562-575.e5. doi: 10.1016/j.molcel.2019.05.025. Epub 2019 Jun 25.

Improved CUT&RUN chromatin profiling tools.
Meers MP, Bryson TD, Henikoff JG, Henikoff S.
Elife. 2019 Jun 24;8:e46314. doi: 10.7554/eLife.46314.

Last Updated: 10/27/2022 1:27:13 PM

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