Michael Paley, MD, PhD

Assistant Professor
Internal Medicine
Rheumatology
Ophthalmology and Visual Sciences
Pathology and Immunology

Immunology Program
Computational and Systems Biology Program
Neurosciences Program

  • 314-273-7778

  • 8045

  • 660 S. Euclid Ave, CSRB 10052

  • paleym@wustl.edu

  • @drmapaley

  • Mechanisms of inflammation in immune-privileged organs

Research Abstract:

Our research interests are focused on mechanisms of inflammation from systemic inflammatory disorders in immune-privileged organs, such as the eye and the brain. This includes HLA-B27+ anterior uveitis in ankylosing spondylitis and neurological inflammation from sarcoidosis (i.e., neurosarcoidosis).

Selected Publications:

Reactogenicity of the Messenger RNA SARS–CoV-2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease
Yang, M. M., Taylor, K. E., Paez, D., Carividi, A., Demissie, E., Pawar, N., El-Qunni, A. A., McMorrow, L. E., Schriefer, R. E., Huang, K., Kinnett, B., Klebert, M., Haile, A., O'Halloran, J. A., Presti, R. M., Kim, W., Ellebedy, A. H., Ciorba, M. A., Paley, M. A., Deepak, P., & 5 others, 2022, (Accepted/In press) In: Arthritis Care and Research.

The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells
Paley, M. A., Baker, B. J., Dunham, S. R., Linskey, N., Cantoni, C., Lee, K., Hassman, L. M., Laurent, J., Roberson, E. D. O., Clifford, D. B. & Yokoyama, W. M., Jun 15 2022, In: Journal of Neuroimmunology. 367, 577860.

Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy
Sultan, H., Rajagopal, R., Rao, P. K., Piggott, K. D., Paley, M. A., Hassman, L. M., Li, A. S., Marshall, B. & Apte, R. S., 2022, In: International Journal of Ophthalmology. 15, 1, p. 89-97 9 p.

B cells: more than just for antibodies in SARS-CoV-2 vaccine responses
Paley, M. A. & Kim, A. H. J., Nov 2021, In: The Lancet Rheumatology. 3, 11, p. e741-e743

Effect of immunosuppression on the immunogenicity of mrna vaccines to sars-cov-2 a prospective cohort study
Deepak, P., Kim, W., Paley, M. A., Yang, M., Carvidi, A. B., Demissie, E. G., El-Qunni, A. A., Haile, A., Huang, K., Kinnett, B., Liebeskind, M. J., Liu, Z., McMorrow, L. E., Paez, D., Pawar, N., Perantie, D. C., Schriefer, R. E., Sides, S. E., Thapa, M., Gergely, M., & 20 others, Nov 1 2021, In: Annals of internal medicine. 174, 11, p. 1572-1585 14 p.

Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis
Rosenbaum, J. T., Harrington, C. A., Searles, R. P., Fei, S. S., Zaki, A., Arepalli, S., Paley, M. A., Hassman, L. M., Vitale, A. T., Conrady, C. D., Keath, P., Mitchell, C., Watson, L., Planck, S. R., Martin, T. M. & Choi, D., Jun 2021, In: American journal of ophthalmology. 226, p. 226-234 9 p.

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
Johnnidis, J. B., Muroyama, Y., Ngiow, S. F., Chen, Z., Manne, S., Cai, Z., Song, S., Platt, J. M., Schenkel, J. M., Abdel-Hakeem, M., Beltra, J. C., Greenplate, A. R., Ali, M. A. A., Nzingha, K., Giles, J. R., Harly, C., Attanasio, J., Pauken, K. E., Bengsch, B., Paley, M. A., & 8 others, 2021, In: Science immunology. 6, 55, eabe3702.

Reduced antibody activity against SARS-CoV-2 B.1.617.2 delta virus in serum of mRNA-vaccinated individuals receiving tumor necrosis factor-α inhibitors
Chen, R. E., Gorman, M. J., Zhu, D. Y., Carreño, J. M., Yuan, D., VanBlargan, L. A., Burdess, S., Lauffenburger, D. A., Kim, W., Turner, J. S., Droit, L., Handley, S. A., Chahin, S., Deepak, P., O'Halloran, J. A., Paley, M. A., Presti, R. M., Wu, G. F., Krammer, F., Alter, G., & 3 others, Dec 10 2021, In: Med. 2, 12, p. 1327-1341.e4

Last Updated: 11/30/2022 10:56:06 AM

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