• McKendree University (2007)

  • Neurosciences

  • David M. Holtzman, M.D.

  • Role of microglia in Alzheimer`s Disease

  • mahant@wustl.edu

Graduate Publications:

Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. 2021 C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron, 109(14):2275-2291.e8.

Huynh TV, Wang C, Tran AC, Tabor GT, Mahan TE, Francis CM, Finn MB, Spellman R, Manis M, Tanzi RE, Ulrich JD, Holtzman DM. 2019 Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Mol Neurodegener, 14(1):37.

Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. 2019 The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science, 363(6429):880-884.

Lessard CB, Malnik SL, Zhou Y, Ladd TB, Cruz PE, Ran Y, Mahan TE, Chakrabaty P, Holtzman DM, Ulrich JD, Colonna M, Golde TE. 2018 High-affinity interactions and signal transduction between Aβ oligomers and TREM2. EMBO Mol Med, 10(11):pii: e9027.

Ulrich JD Ulland TK, Mahan TE, Nyström S, Nilsson KP, Song WM, Zhou Y, Reinartz M, Choi S, Jiang H, Stewart FR, Anderson E, Wang Y, Colonna M, Holtzman DM. 2018 ApoE facilitates the microglial response to amyloid plaque pathology. J Exp Med, 215(4):1047-1058.

Huynh TV, Liao F, Francis CM, Robinson GO, Serrano JR, Jiang H, Roh J, Finn MB, Sullivan PM, Esparza TJ, Stewart FR, Mahan TE, Ulrich JD, Cole T, Holtzman DM. 2017 Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron, 96(5):1013-1023.

Holth JK, Mahan TE, Robinson GO, Rocha A, Holtzman DM. 2017 Altered sleep and EEG power in the P301S Tau transgenic mouse model. Ann Clin Transl Neurol, 4(3):180-190.

Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M. 2016 TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J Exp Med, 213(5):667-75.

Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. 2015 Analysis of in vivo turnover of tau in a mouse model of tauopathy. Mol Neurodegener, 10():55.

Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, Sutphen CL, Holtzman DM. 2015 Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. J Clin Invest, 125(6):2463-7.

Liao F, Jiang H, Srivatsan S, Xiao Q, Lefton KB, Yamada K, Mahan TE, Lee JM, Shaw AS, Holtzman DM. 2015 Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model. Mol Neurodegener, 10(12):.

Yanamandra K, Jiang H, Mahan TE, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM. 2015 Anti-tau antibody reduces insoluble tau and decreases brain atrophy. Ann Clin Transl Neurol, 2(3):278-88.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. 2014 Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. J Exp Med, 11(13):2487-96.

Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. 2014 Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci USA, 111(41):E4376-85.

Last Updated: 1/11/2018 10:43:45 AM

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