• Georgetown University (2015)

  • Developmental, Regenerative and Stem Cell Biology

  • Samantha A. Morris, Ph.D.

  • Intestinal Engineering: Using Single-Cell Approaches to Investigate Intestinal Reprogramming and Tissue Engineering

  • s.waye@wustl.edu

Research

Use scRNA-seq technology to better understand adaptation after small bowel resection; engineer intestinal organoids to undergo regional reprogramming in vitro for use in high throughput studies, regenerative treatments, and potential modeling of short bowel syndrome.

1. Gain better understanding of the effects of the adaptation process after small bowel resection (SBR) on a molecular level and investigate potential upstream effectors of molecular change using scRNA-seq.
2. Use direct reprogramming to induce regional reprogramming in distal organoids for use in modeling adaptation after SBR in vitro.

Graduate Publications:

Minn KT, Dietmann S, Waye SE, Morris SA, Solnica-Krezel. 2021 Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids. Stem Cell Reports, ():S2213-6711(21)00162-4.

Biddy BA, Kong W, Kamimoto K, Guo C, Waye SE, Sun T, Morris S. 2018 Single-cell mapping of lineage and identity in direct reprogramming. Nature, 564(7735):219-24.

Seiler KM, Waye SE, Kong W, Kamimoto K, Bajinting A, Goo WH, Onufer EJ, Courtney C, Guo J, Warner BW, Morris SA. Single-Cell Analysis Reveals Regional Reprogramming during Adaptation to Massive Small Bowel Resection in Mice. Cell Mol Gastroenterol Hepatol, ():pii: S2352-345X(19)30079-7.

Last Updated: 9/9/2019 4:20:05 PM

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