• University of Texas-Austin (2010)

  • Molecular Cell Biology

  • Grant Challen, Ph.D.

  • Investigating the potential novel role(s) of DNA methyltransferase 3A (DNMT3A) in the hematopoietic stem cell (HSC) function.

  • kohw@wustl.edu

Graduate Publications:

Zhang CR, Ostrander EL, Kukhar O, Mallaney C, Sun J, Haussler E, Celik H, Koh WK, King KY, Gontarz P, Challen GA. 2022 Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21. Blood Cancer Discov, ():OF1-OF20.

Celik H, Krug E, Zhang CR, Han W, Issa N, Koh WK, Bjeije H, Kukhar O, Allen M, Li T, Fisher DA, Fowles JS, Wong TN, Stubbs MC, Koblish HK, Oh ST, Challen GA. 2021 A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms. Cancer Discov, 11(12):3126-41.

Ostrander EL, Kramer AC, Mallaney C, Celik H, Koh WK, Fairchild J, Haussler E, Zhang CRC, Challen GA. 2020 Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, ():pii: S2213-6711(20)30067-9.

Mallaney C, Ostrander EL, Celik H, Kramer AC, Martens A, Kothari A, Koh WK, Haussler E, Iwamori N, Gontarz P, Zhang B, Challen GA. 2019 Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis. Leukemia, ():Epub ahead of print.

Celik H, Koh WK, Kramer AC, Ostrander EL, Mallaney C, Fisher DAC, Xiang J, Wilson WC, Martens A, Kothari A, Fishberger G, Tycksen E, Karpova D, Duncavage EJ, Lee Y, Oh ST, Challen GA. 2018 JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell, 34(5):741-56.

Chen X, Kim IK, Honaker Y, Paudyal SC, Koh WK, Sparks M, Li S, Piwnica-Worms H, Ellenberger T, You Z. 2015 14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem, 290(15):12300-12.

Back To Top

Follow us: