Min Woo Kim (MSTP in PhD training)

  • Anaheim, CA

  • University of California-Los Angeles (2016)

  • Immunology

  • Jonathan Kipnis, Ph.D.

  • Protecting against autoimmunity through the presentation of autoantigens

  • kim.minwoo@wustl.edu

Research

The focus of my project is to better understand central nervous system (CNS) autoantigens and their function in CNS immunosurveillance. Utilizing myelin oligodendrocyte glycoprotein (MOG)35-55 peptide immunization in C57BL/6 mice as my model for active experimental autoimmune encephalitis (EAE), I observed that immunizing myelin basic protein (MBP) together with MOG35-55 peptide in C57BL/6 mice could mildly suppress the EAE phenotype. Further analyses by flow cytometry unveiled marked increase in regulatory T cells in the CNS-draining lymph nodes in mice co-immunized with MOG and MBP when compared to MOG immunization alone. The role MBP presentation plays in modulating T cell response towards that of suppression remains a fascinating question.

Last Updated: 8/17/2022 2:51:23 PM

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