• St. Louis University (2015)

  • Molecular Genetics and Genomics

  • Liang Shan, Ph.D.

  • Determining and overcoming barriers in translating HIV-1 protease mediated activation of the CARD8 inflammasome for an HIV cure.

  • kolin.clark@wustl.edu

Research

We recently showed that the inflammasome sensor CARD8 was able to sense intracellular HIV protease activity leading to pyroptosis of HIV-1 infected cells. This premature intracellular protease activity is mediated through the addition of non-nucleoside reverse transcriptase inhibitors (NNRTIs). My work is on understanding both host and viral factors that may affect the efficacy of CARD8 sensing and thereby an HIV cure. I also study ways in which we can enhance this sensing through sensitization of the CARD8 inflammasome through chemical inhibition of its negative regulator DPP9.

Graduate Publications:

Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, Harlan GH, DeSelm CJ, Presti RM, Kutluay SB, Shan L.. 2022 CARD8 is an inflammasome sensor for HIV-1 protease activity. Science, 371(6535):eabe1707.

Last Updated: 3/9/2022 12:29:36 PM

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