Steven Yang (MSTP in PhD training)

  • Princeton, NJ

  • University of Pennsylvania (2015)

  • Immunology

  • Kory J. Lavine, M.D., Ph.D.

  • Mechanisms of CAR T therapy in cardiac fibrosis

  • steven.yang@wustl.edu

Research

Fibroblast activation protein has been shown to be elevated in fibroblasts in failing, but not control, hearts in both humans and mice. Chimeric antigen receptor T cells may be directed against fibroblast activation protein and it has been shown that these CAR T cells can prevent fibrosis and rescue systolic function. My project seeks to understand how these engineered T cells remodel the cardiac immune landscape and what effects these changes may have on preventing adverse cardiac remodeling and preserving cardiac function.

Last Updated: 8/17/2022 3:56:17 PM

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