• Ramnarain Ruia College (2014)

  • Molecular Cell Biology

  • Matthew L. Goodwin, M.D., Ph.D.

  • I am studying the role of phosphorylated IDH2 in the Pptc7 KO phenotype

  • s.bhagwat@wustl.edu


Pptc7 is a mitochondrial phosphatase, the absence of which leads to post-natal death in mice. The exact function of this phosphatase is still unclear. IDH2 phosphorylation is seen to be upregulated in Pptc7 KO tissue and I am currently trying to understand how this modification contributes to the phenotype, the molecular mechanisms behind this modification and its potential role in mitochondrial dysregulation.

Last Updated: 1/7/2022 2:08:58 PM

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