• Drury University (2019)

  • Cancer Biology

  • Abby M. Green, MD

  • Determining the impact of global APOBEC3A mutagenesis on gene expression

  • rdeweerd@wustl.edu

Research

The APOBEC3 family of cytosine deaminases are an endogenously expressed DNA and RNA mutators, functioning canonically as viral restriction factors. Some APOBEC3 members, however, are able to localize to the nucleus and act on genomic DNA. The most potent family member, APOBEC3A, binds to cytosine (C) bases in DNA and RNA, as well as methylated cytosines (5mC) in DNA. Cellular processing of deaminated C bases can result in base mutations- the pattern of these mutations, or signatures, is highly prevalent in human cancers. We are interested in identifying the mechanisms which determine APOBEC3A mutagenesis patterns at the cellular level and how APOBEC3A activity contributes to changes in overall cellular function.

Last Updated: 10/5/2022 10:26:29 AM

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