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Yousef Abu-Amer, Ph.D.
- Investigating molecular mechanisms underlying inflammation-induced degenerative skeletal diseases including joint degeneration, inflammatory arthritis and osteolysis
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Sarah D. Ackerman, Ph.D.
- Understanding how glial cells instruct proper nervous system development and function
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Jennifer Alexander-Brett, M.D., Ph.D.
- Respiratory immunobiology, with particular interest in cytokine pathways associated with lung epithelial progenitors
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Rajendra S. Apte, M.D., Ph.D.
- Innate immunity and immune effector mechanisms in the retina; oxidative stress and cell death; models of developmental angiogenesis and neovascularization; inflammation and photoreceptor survival; macular degeneration
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David L. Bark, Ph.D.
- Applying biomechanics and mechanobiology (the interaction and response of cells and tissue to mechanical forces) to diagnose, study, and treat various forms of cardiovascular disease.
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Steven Bassnett, Ph.D.
- Ocular cell biology
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Luis F.Z. Batista, Ph.D.
- Understanding the role of DNA damage and RNA degradation during tissue homeostasis, regeneration, aging, and cancer
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Carmen Bergom, M.D., Ph.D.
- Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury
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Irving Boime, Ph.D.
- Placental and pituitary hormone genes
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Paul C. Bridgman, Ph.D.
- Cell biology of developing nerve and muscle cells
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Andreas H. Burkhalter, Ph.D.
- Structure and physiology of neuronal circuits in mouse visual cortex
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Valeria Cavalli, Ph.D.
- Cellular, Molecular and Epigenetic control of axon regeneration
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Douglas L. Chalker, Ph.D.
- Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena
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Grant Challen, Ph.D.
- Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells
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David Y. Chen, M.D.,Ph.D.
- Defining the genetic and epigenetic drivers of premalignant states in skin cancer
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Feng Chen, Ph.D.
- Molecular genetic studies of urogenital diseases
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Shiming Chen, Ph.D.
- Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas
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Zhou-Feng Chen, Ph.D.
- Molecular and cellular mechanisms of itch sensation
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Milan G. Chheda, M.D.
- Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
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Kyunghee Choi, Ph.D.
- Angioimmune interface in development, tissue regeneration, and cancer
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Matt Christopher, M.D., Ph.D.
- Improve outcomes for patients with acute myeloid leukemia (AML) and other hematopoietic malignancies utilizing genomic and molecular biology techniques
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Brian Clark, Ph.D.
- Analysis of the temporally regulated program of retinal cell type specification.
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F. Sessions Cole, M.D.
- Genetic lung disease, Surfactant protein B, and rare diseases in infants
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Jonathan Cooper, Ph.D.
- Studying the pathogenesis of Batten disease and other lysosomal storage disorders
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Bryan Copits, Ph.D.
- How different types of neurons encoding somatosensory modalities are assembled into functional circuits
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Joseph C. Corbo, M.D., Ph.D.
- (1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease
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Erika C. Crouch, Ph.D., M.D.
- Structure and function of surfactant protein D (SP-D)
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David T. Curiel, M.D., Ph.D.
- To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery
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Brian J. DeBosch, M.D., Ph.D.
- To elucidate gut and hepatic determinants of metabolic disease, including diabetes mellitus, metabolic syndrome and their complications
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Aaron DiAntonio, M.D., Ph.D.
- Neural circuits in development and disease
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Li Ding, Ph.D.
- Cancer genomics and proteomics
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Ian W. Duncan, Ph.D.
- Temporal control of target gene specificity for developmental regulators in Drosophila
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Takeshi Egawa, M.D., Ph.D.
- Gene regulation for lymphocyte development and adaptive immune responses
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Guy M. Genin, Ph.D.
- Interfaces and adhesions in physiology and nature
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Matthew I. Goldsmith, M.D.
- Skeletal growth and regeneration in zebrafish
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Geoffrey J. Goodhill, Ph.D.
- Understanding the computational principles that underly brain development, using a combination of experimental and theoretical approaches
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Michael J. Greenberg, Ph.D.
- The Greenberg lab seeks to understand the molecular and cellular biophysics of heart disease, with the goal of engineering disease models and precision therapeutics
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Farshid Guilak, Ph.D.
- Focuses on the role of biomechanical factors in the onset, progression, and treatment of osteoarthritis and other joint diseases.
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David H. Gutmann, M.D., Ph.D.
- Leveraging neurogenetic disorders to study normal brain development, cancer, and autism
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Carmen Halabi, M.D., Ph.D.
- Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease
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Erik D. Herzog, Ph.D.
- Molecular, cellular and circuit analysis of circadian rhythms in mammals
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Didier Hodzic, Ph.D.
- Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration
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James J. Hsieh, M.D., Ph.D.
- Integrate contemporary research tools to quickly improve human cancer care
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Jing W. Hughes, M.D., Ph.D.
- Cilia functions in islet cell crosstalk, beta cells in diabetes, live-cell microscopy
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Benjamin D. Humphreys, M.D., Ph.D.
- Define cell hierarchies in kidney injury and repair and thereby identify the critical cell types in kidney repair and fibrosis
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Shin-ichiro Imai, M.D., Ph.D.
- Understanding the molecular mechanism of aging and longevity in mammals
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Sanjay Jain, M.D., Ph.D.
- Interactions between the nervous and genitourinary systems during development, molecular basis for heterogeneity in progenitors and their lineage commitments in the GU tract, injury and regeneration using animal models, mechanisms of malformations using organoids from iPSCs
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Aaron Johnson, Ph.D.
- Molecular mechanisms of skeletal and cardiac muscle development and disease
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Yoon A Kang, Ph.D.
- Decoding cell fate decision mechanisms to modulate lineage output for therapeutic purpose
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Celeste M. Karch, Ph.D.
- Understanding the molecular and cellular mechanisms underlying tauopathies
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Charles Kaufman, MD, Ph.D.
- Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease
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Daniel Kerschensteiner, M.D.
- Visual system neuroscience and vision restoration
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Jae-Sung Kim, Ph.D.
- Mitochondria and autophagy in ischemic liver injury and liver aging
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S. Kerry Kornfeld, M.D., Ph.D.
- organismal aging; zinc homeostasis and roles of zinc during cell differentiation.
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Kristen L. Kroll, Ph.D.
- Transcriptional and epigenetic regulation of neural development and its dysregulation to cause neurodevelopmental disorders
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Kory J. Lavine, M.D., Ph.D.
- Identify signaling pathways that mediate cardiac tissue repair/regeneration and heart failure pathogenesis.
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Qingyun "Tristan" Li, Ph.D.
- Microglial biology and neuro-immune interactions in development, aging and disease
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Ta-Chiang Liu, M.D., Ph.D.
- Understanding how host genetics and environmental factors interact to shape gut metabolism leading to inflammation
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Irfan J. Lodhi, Ph.D.
- Role of lipid metabolism in obesity, diabetes and other metabolic diseases
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Gregory D. Longmore, M.D.
- Cell Motility and Cancer Metastasis
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Liang Ma, Ph.D.
- Understanding genetic pathways regulating epithelial differentiation
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Susan Mackinnon, M.D.
- Investigation of peripheral nerve injury and regeneration
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Jeffrey Magee, M.D., Ph.D.
- Developmental context and genetic variation as underlying mechanisms of childhood cancer
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Moe Mahjoub, Ph.D.
- The microtubule cytoskeleton in health and disease
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Gabriel Mbalaviele, Ph.D.
- Role of inflammasomes in disease
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Audrey McAlinden, Ph.D.
- Molecular mechanisms regulating skeletal development
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Helen McNeill, Ph.D.
- Coordinating cell proliferation and cell organization in organ development
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Robert P. Mecham, Ph.D.
- Cell-matrix interactions, extracellular matrix and development, vascular development and disease
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Gretchen A. Meyer, Ph.D.
- Understanding how changes at the molecular and cellular level in skeletal muscle affect muscle structure and function
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Craig Micchelli, Ph.D.
- The biology of stem cells
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Jeffrey Milbrandt, M.D., Ph.D.
- Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease
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Jeffrey R. Millman, Ph.D.
- Differentiation to and maturation of pancreatic insulin-producing β cells from human pluripotent stem cells capable of rapidly reversing diabetes
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Jeffrey H. Miner, Ph.D.
- Human genetic kidney disease: Insights through mouse models
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Mayssa H. Mokalled, Ph.D.
- Mechanisms of neural regeneration using zebrafish and mouse model systems
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Josh L. Morgan, Ph.D.
- Use advanced cellular imaging techniques to investigate how neurons organize themselves into image processing circuits
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Samantha A. Morris, Ph.D.
- Developing new single-cell technologies to create high-resolution maps of lineage and identity; Manipulating gene regulatory networks, via direct lineage reprogramming, to generate clinically valuable cell types
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Kenneth M. Murphy, M.D., Ph.D.
- Selecting the correct immune response to pathogens – development of dendritic cells and lymphocyte subsets
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David M. Ornitz, M.D., Ph.D.
- Regulation of lung, skeletal, and cardiovascular development, injury response, and regeneration by Fibroblast Growth Factors
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Philip Osdoby, Ph.D.
- Bone remodeling cell and molecular events of osteoclast activity and development
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B. Duygu Özpolat, Ph.D.
- Mechanisms of reproductive cell regeneration and development
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Sid Puram, M.D., Ph.D.
- Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics
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Maria S. Remedi, Ph.D.
- Channels: diabetes, obesity and brain disorders
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Stacey L. Rentschler, M.D., Ph.D.
- Direct reprogramming of cells into specialized cardiac conduction tissues
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Deborah C. Rubin, M.D.
- Intestinal stem cells and the stem cell niche in intestinal injury/short bowel syndrome and colitis associated colon cancer
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David A. Rudnick, M.D., Ph.D.
- Molecular mechanisms of liver injury and regeneration
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Lawrence B. Salkoff, Ph.D.
- How ion channels function in physiology and behavior
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Tim B. Schedl, Ph.D.
- Control of germline stem cells and meiotic development in C. elegans
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Erica L. Scheller, D.D.S., Ph.D.
- Impact of neuroendocrine signals on bone loss and marrow adiposity in diseases including periodontitis, arthritis, and diabetes
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Laura G. Schuettpelz, M.D., Ph.D.
- Regulation of hematopoietic stem cells (HSCs) by inflammation
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Lori A. Setton, Ph.D.
- Understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus
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Lavinia Sheets, Ph.D.
- We use zebrafish as a model for human hearing and balance with the goal of protecting and repairing inner ears from damage.
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Jie Shen, Ph.D.
- Focused on injury, repair, and regeneration of musculoskeletal tissues with the goal to understand the progenitor cell population, signals, and role of inflammation on tissue injury and regeneration at the cellular and molecular level
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Gary A. Silverman, M.D., Ph.D.
- The cellular response to life threatening human diseases.
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James B. Skeath, Ph.D.
- Genetic analysis of neural and muscular development in the Drosophila embryo
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Lilianna Solnica-Krezel, Ph.D.
- Inductive and morphogenetic processes that establish and shape germ layers during vertebrate embryogenesis, using zebrafish and embryonic stem cell models
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George P. Souroullas, Ph.D.
- Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.
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David H. Spencer, M.D., Ph.D.
- My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.
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Amber Stratman, Ph.D.
- The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.
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Paul H. Taghert, Ph.D.
- Circadian physiology and behavior
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Steven L. Teitelbaum, M.D.
- Molecular mechanisms of osteoclast differentiation and bone resorption
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