​Molecular Genetics and Genomics

   
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  • Sarah D. Ackerman, PhD - Understanding how glia shape developmental and pathological plasticity
  • Dustin Baldridge, MD,PhD - Utilizing the power of genetics to elucidate the molecular pathogenesis of disease and transform patient care
  • Megan T. Baldridge, MD, PhD - Defining the mechanisms behind and effects of the interactions between commensal bacteria, pathogens and innate immunity
  • Thomas J. Baranski, MD, PhD - Signal transduction by G proteins and pathogenesis of diabetes
  • Wayne M. Barnes, PhD - Possible cure for MS: intravenous access by myelin-binding aptamer; PCR at one temp; RT-enabled Taq pol.
  • Luis F.Z. Batista, PhD - Understanding the role of DNA damage and RNA degradation during tissue homeostasis, regeneration, aging, and cancer
  • Jeffrey J. Bednarski II, MD, PhD - Understanding the signals that direct early B cell development
  • Yehuda Ben-Shahar, PhD - Molecular, cellular, genetic and evolutionary mechanisms of behavior
  • Carmen Bergom, MD, PhD - Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury
  • Stephen M. Beverley, PhD - Molecular genetics of protozoan parasites - virulence and their viruses
  • Joshua Blodgett, PhD - Interdisciplinary questions surrounding bacterial small molecule production
  • Ryan Bogdan, PhD - How genetic variation and environmental experience contribute to individual differences in brain function, behavior, and psychopathology
  • Arpita Bose, PhD - Microbial metabolisms and their influence on biogeochemical cycling
  • Michael R. Brent, PhD - Computational genomics, human genetics, systems biology, transcriptional regulatory networks
  • Jeremy D. Buhler, PhD - Developing algorithms and architectures for large-scale biosequence comparison, genome annotation, and metagenomics
  • Peter M.J. Burgers, PhD - Molecular Biology of DNA replication and damage response in yeast and human
  • Michael G. Caparon, Jr, PhD - Genetics and virulence of the pathogenetic streptococci
  • Daniel Castro, PhD - Understanding the role of endogenous opioids in affective neuroscience and metabolic homeostasis
  • Douglas L. Chalker, PhD - Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena
  • Grant Challen, PhD - Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells
  • Aadel A. Chaudhuri, MD, PhD - Liquid biopsy cancer detection
  • David Y. Chen, MD,PhD - Defining drivers of premalignant states in skin
  • Shiming Chen, PhD - Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas
  • Yao Chen, PhD - Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals
  • Ying Maggie Chen, MD, PhD - Understanding the molecular mechanisms of primary nephrotic syndrome (NS)
  • Zhou-Feng Chen, PhD - affective touch, itch, pain, GPCR and prosocial behavior
  • Milan G. Chheda, MD - Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
  • Roberto Civitelli, MD - Connexins, cadherins in bone cell interactions with cancer and energy metabolism
  • Brian Clark, PhD - Analysis of the temporally regulated program of retinal cell type specification.
  • Barak A. Cohen, PhD - Genomic analyses of regulatory networks, Non-coding disease variants
  • Graham A. Colditz, MD, DrPH - Causes and prevention of breast cancer, premalignant lesions, risk stratification
  • Jonathan Cooper, PhD - Disease mechanisms and treatments for inherited childhood neurodegeneration
  • Bryan Copits, PhD - We study how different types of neurons encoding somatosensory modalities are assembled into functional circuits in both humans and model organisms.
  • Joseph C. Corbo, MD, PhD - (1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease
  • Sharon Cresci, MD - Genetic variation in the variable response to pharmacologic treatment (i.e. Pharmacogenomics) of cardiovascular disease; specifically individuals with both diabetes mellitus and coronary artery disease.
  • Carlos Cruchaga, PhD - The goal of my lab is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches.
  • David T. Curiel, MD, PhD - To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery
  • Gautam Dantas, PhD - (1) Dynamics, ecology, and evolution of antibiotic resistance, (2) Engineering enhanced probiotics to treat GI disorders, (3) Engineering microbial biofuel catalysts
  • Victor Davila-Roman, MD - Noninvasive characterization of heart function in patients with high blood pressure
  • Brian J. DeBosch, MD, PhD - To elucidate gut and hepatic determinants of metabolic disease, including diabetes mellitus, metabolic syndrome and their complications
  • Jorge Di Paola, MD - The genetics of bleeding and thrombotic disorders and mechanisms of platelet activation
  • Li Ding, PhD - Cancer Proteogenomics and Cancer Models
  • Sergej Djuranovic, PhD - Molecular mechanisms of translational control
  • Gerald W. Dorn, II, MD - Cellular, Molecular, And Genetic Studies Of Cardiac Hypertrophy And Heart Failure
  • Joseph D. Dougherty, PhD - Human Psychiatric Genetics, Mouse Models, Cell Type Specific Gene Expression Profiling, Translation, Astrocytes.
  • Bettina F. Drake, PhD, MPH - Identifying preventive strategies to reduce cancer disparities
  • Ian W. Duncan, PhD - Temporal control of target gene specificity for developmental regulators in Drosophila
  • Susan K. Dutcher, PhD
  • John R. Edwards, PhD - Understanding epigenomic abnormalities in breast cancer
  • Gabor Egervari, PhD - We aim to understand how metabolism influences epigenetics, gene expression and behavior, particularly in the context of substance use disorders and neurodegeneration
  • Francesca Ferraro, MD, PhD - We use both mouse models and patient samples of acute myloid leukemia to understand leukemogenesis and to identify novel therapeutic targets.
  • Harrison W. Gabel, PhD - Exploration of functions for neuron-specific regulators of gene expression, leveraging genes and mechanisms implicated in human neurologic disease to point us toward critical pathways in the brain.
  • Matthew I. Goldsmith, MD - Skeletal growth and regeneration in zebrafish
  • Matthew L. Goodwin, MD, PhD - Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways
  • Abby M. Green, MD - The etiology of mutagenesis and genome instability in pediatric cancers
  • Eric Greer, PhD - Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise
  • Malachi Griffith, PhD - Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies
  • Christina A. Gurnett, MD, PhD - Gene discovery, variant interpretation using high-throughput functional assays
  • David H. Gutmann, MD, PhD - Leveraging neurogenetic disorders to study normal brain development, cancer, and autism
  • Carmen Halabi, MD, PhD - Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease
  • Gabriel Haller, PhD - Genetic underpinnings of neurological/neurosurgical disorders
  • Angela Hirbe, MD, PhD - Utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.
  • James J. Hsieh, MD, PhD - Integrate contemporary research tools to quickly improve human cancer care
  • Shin-ichiro Imai, MD, PhD - Understanding the molecular mechanism of aging and longevity in mammals
  • Sanjay Jain, MD, PhD - Interactions between the nervous and genitourinary systems during development, molecular basis for heterogeneity in progenitors and their lineage commitments in the GU tract, injury and regeneration using animal models, mechanisms of malformations using organoids from iPSCs
  • Aimee S. James, PhD, MPH - Cancer prevention and control, health disparities and community-based research
  • Sheng Chih (Peter) Jin, PhD - We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying diseases
  • Aaron Johnson, PhD - Molecular mechanisms of skeletal and cardiac muscle development and disease
  • Andrew L. Kau, MD, PhD - Understanding the immune-modifying capacity of gastrointestinal and airway microbes through the lens of allergy
  • Charles Kaufman, MD, PhD - Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease
  • Elizabeth A. Kellogg, PhD - Identifying deep similarities among plants as apparently disparate as rice, wheat, maize, and the other cereals
  • Dineo Khabele, MD - clinical and translational research in gynecologic oncology, with a focus on ovarian cancer
  • Albert H. Kim, MD, PhD - Genetic and epigenetic changes that drive malignant behavior in brain tumors
  • Jonathan Kipnis, PhD - We study complex interactions between the immune and nervous systems in health and disease
  • S. Kerry Kornfeld, MD, PhD - organismal aging; zinc homeostasis and roles of zinc during cell differentiation.
  • Barbara N. Kunkel, PhD - Molecular genetic analysis of disease development in Pseudomonas syringae-Arabidopsis interactions
  • Michael J. Landis, PhD - Modeling the evolution of species with stochastic processes
  • Heather A. Lawson, PhD - Integration of whole-genome sequence with phenotypic data to understand parent-of-origin genetic effects and gene-by-environment interactions
  • Timothy J. Ley, MD - Study of normal versus leukemic blood cell development and immunology
  • Qingyun "Tristan" Li, PhD - Microglial biology and neuro-immune interactions in development, aging and disease
  • Daniel C. Link, MD - Regulation of normal and malignant hematopoiesis
  • Irfan J. Lodhi, PhD - Role of lipid metabolism in obesity, diabetes and other metabolic diseases
  • Jeffrey Magee, MD, PhD - Developmental context and genetic variation as underlying mechanisms of childhood cancer
  • Nupam P. Mahajan, PhD - How tyrosine phosphorylation regulates epigenetic processes that affect cellular homeostasis and cancer cell survival
  • Christopher Maher, PhD - Translational Cancer Genomics; Noncoding RNAs
  • Helen McNeill, PhD - Coordinating cell proliferation and cell organization in organ development
  • Michael Meers, PhD - Understanding the molecular determinants of cellular diversity
  • Blake C. Meyers, PhD - The function, biogenesis & evolution of small RNAs in plants
  • Craig Micchelli, PhD - The biology of stem cells
  • Jeffrey Milbrandt, MD, PhD - Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease
  • Rob Mitra, PhD - Technology development for functional genomics and systems biology
  • Makedonka Mitreva, PhD - Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome
  • Mayssa H. Mokalled, PhD - Mechanisms of neural regeneration using zebrafish and mouse model systems
  • Shamim Mollah, PhD - Utilize AI technologies to understand cellular circuitry and gene regulatory network of cancer and other rare diseases through integration of multi-omics data, special emphasis on epigenetics and the DNA–histone protein complex
  • Samantha A. Morris, PhD - Developing new single-cell technologies to create high-resolution maps of lineage and identity; Manipulating gene regulatory networks, via direct lineage reprogramming, to generate clinically valuable cell types
  • Nima Mosammaparast, MD, PhD - Understanding how RNA modifications influence transcription, signaling, and genomic integrity
  • Brian Muegge, MD, PhD - Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases
  • Mary Mullen, MD - Targeting the DNA damage response in order to overcome chemotherapy resistance
  • Natalie M. Niemi, PhD - Understanding how mitochondria are built, regulated, and maintained
  • Michael L. Nonet, PhD - Molecular genetic analysis of synaptic development and function
   
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