Philip V. Bayly, Ph.D.

Lee Hunter Distinguished Professor and Chair
Mechanical Engineering & Materials Science
Biomedical Engineering

Neurosciences Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-935-6081

  • 314-935-4014

  • pvb@wustl.edu

  • MR imaging of motion, mechanics of brain injury, impact, vibration, wave motion

  • The application of nonlinear dynamics and vibrations to mechanical and biomedical systems

Research Abstract:

My research involves the measurement and modeling of dynamic mechanical phenomena in biological systems. In collaboration with Jin-Yu Shao (biomedical engineering) and Susan Dutcher (genetics), I study flagellar waveforms and measure mechanical properties of flagella using an optical trap system. We are currently extending this approach to characterize the elastic properties and active behavior of human cilia. With Larry Taber (biomedical engineering) and Anders Carlsson, I have built mathematical models of the subcellular and tissue-scale biomechanical processes involved in morphogenesis. We have obtained quantitative measurements of deformation during development of the embryo, particularly the brain and eye. I study dynamic deformation and mechanical properties of the brain in the context of traumatic brain injury. These projects exploit advanced imaging methods and image processing techniques developed specifically to quantify dynamic physical processes; they all involve collaboration between engineers and medical or biological researchers.

Mentorship and Commitment to Diversity Statement:
Diversity, equity and inclusion: I am committed to providing a supportive and inclusive place to work, for every member of my lab and to all those with whom we interact, regardless of race, ethnicity, gender identity, orientation, socioeconomic status, and religious or political affiliation.

I have worked to establish undergraduate research opportunities through the Washington University Summer Engineering Fellowship (WUSEF) program. As a professor and department chair, I have helped our Department increase our faculty and students who are women and from groups traditionally underrepresented in engineering. I truly enjoy and value engineering research and education, and will continue to work to ensure that all who wish to pursue engineering have an equal chance to participate and succeed.

Selected Publications:

Pubmed:  https://www.ncbi.nlm.nih.gov/myncbi/philip.bayly.1/bibliography/public/

Google scholar:  https://scholar.google.com/citations?hl=en&user=wY-Wy6IAAAAJ&view_op=list_works&sortby=pubdate

Selected publications

129. Hou Z, Bayly PV, Okamoto RJ. Shear wave speeds in
nearly-incompressible fibrous materials with two fiber families. 
J Acoust Soc Am2021 Feb;149(2):1097. doi: 10.1121/10.0003528. PubMed PMID: 33639778; PubMed Central PMCID:
PMC7878018.

128. Escarcega JD, Knutsen AK, Okamoto RJ, Pham DL, Bayly
PV. 
Natural
oscillatory modes of 3D deformation of the human brain in vivo. 
J Biomech2021 Feb 10;119:110259. doi: 10.1016/j.jbiomech.2021.110259. [Epub ahead of print] PubMed
PMID: 33618329.

127. Kim M, Bayly PV, Meacham JM. Motile cells as probes for
characterizing acoustofluidic devices. 
Lab Chip2021 Feb 9;21(3):521-533. doi: 10.1039/d0lc01025a. PubMed PMID: 33507201.

126. Manduca A, Bayly PJ, Ehman RL, Kolipaka A, Royston TJ,
Sack I, Sinkus R, Van Beers BE. MR elastography: Principles, guidelines, and
terminology.
Magn Reson Med. 2020 Dec
9. doi: 10.1002/mrm.28627. Epub ahead of print. PMID: 33296103.

125. Knutsen AK, Gomez AD, Gangolli M, Wang W-T, Chan D, Lu
Y-C, Christoforou E, Prince JL, Bayly PV, Butman JA, Pham DL. In vivo estimates
of axonal stretch and 3D brain deformation during mild head impact. In press.
Brain Multiphysics. 2020.

124. McGarry M, Van Houten E,
Guertler CA, Okamoto RJ, Smith D, Sowinski D, Johnson CL, Bayly PV, Weaver J, Paulsen
K.
A Heterogenous, Time Harmonic, Nearly Incompressible Transverse Isotropic Finite Element Brain Simulation for MR Elastography. doi:
10.1088/1361-6560/ab9a84. Epub ahead of print.
Physics in Medicine and Biology. 2020.

123. Smith D, Guertler CA, Okamoto RJ, Romano A, Bayly PV,
Johnson CL. Multi-Excitation MR Elastography of the Brain: Wave Propagation in
Anisotropic White Matter.
J Biomech Eng.
2020. doi: 10.1115/1.4046199. [Epub ahead of print] PubMed PMID: 32006012.

122. Guertler CA, Okamoto RJ, Ireland J, Pacia C, Garbow JR,
Chen H, Bayly PV. Estimation of Anisotropic Material Properties of Soft Tissue
by MRI of Ultrasound-induced Shear Waves.
J Biomech Eng. 2020. doi:10.1115/1.4046127. [Epub ahead of print] PubMed
PMID: 31980814. 

121. Hou Z, Okamoto RJ, Bayly PV. Shear wave propagation and
estimation of material parameters in a nonlinear, fibrous material.
J Biomechanical Engineering. Epub ahead
of print. doi:10.1115/1.4044504. 2019.

120. Kim M, Huff E, Bottier M, Dutcher SK, Bayly PV, Meacham
JM. 
Acoustic
trap-and-release for rapid assessment of cell motility. 
Soft Matter. 2019 May 29;15(21):4266-4275.  doi:10.1039/c9sm00184k. PubMed PMID: 30968924.

119. Bottier M, Thomas KA, Dutcher SK, Bayly PV. How Does
Cilium Length Affect Beating?
Biophys J.
2019. 116(7):1292-1304. doi: 10.1016/j.bpj.2019.02.012. PMID: 30878201; PMCID:
PMC6451027.


Last Updated: 3/23/2021 3:06:06 PM

Back To Top

Follow us: