Tamara Hershey, Ph.D.


Neurosciences Program

  • 314-362-5593

  • 314-362-0168

  • 4525 Scott Ave, East Bldg

  • tammy@wustl.edu

  • http://hersheylab.wustl.edu/

  • neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood

  • Clinical neuroscience of diabetes and related diseases

Research Abstract:

Using neuroimaging (MRI, fMRI, Diffuse Optical Tomography and PET) and behavioral techniques, we study:
1) How severe hypoglycemia and chronic hyperglycemia affect the brain in diabetes, particularly during development.
2) The neurodevelopmental and neurodegenerative changes in Wolfram syndrome.  3) The relationship between obesity and the brain, and any relationships to behavioral features and weight loss, and 4) how deep brain stimulation of the subthalamic nucleus affects neural circuitry and behavior in Parkinson disease.

Mentorship and Commitment to Diversity Statement:
Mentorship: My mentoring relationships evolve as each trainee develops ownership of their science, skills and career. At the beginning, my input can be more active in terms of building that sense of ownership and shaping critical thinking and scientific development. As trainees dig deeper into their work and develop expertise, my input may become more conceptual and forward thinking. However, I am always available to help solve any problems that may interfere with their development as scientists and well-rounded individuals. To ensure that these relationships are healthy and useful, I am explicit in explaining my expectations, resources, opinions vs facts, and I encourage trainees to regularly consult with others. I reserve 1 hr / week to meet with each trainee through the entire course of the mentoring relationship. The agenda of these meetings is set by the trainees. Although we always discuss progress on projects and their program,  we also discuss career development, academia generally,  personal difficulties and fun things we did over the weekend. Through these regular open-ended discussions, we build trust and solve problems together. I try to be the best advocate that I can be for all my trainees, postdocs, faculty, staff and students by supporting their growth towards their own goals. In addition, I regularly attend structured learning experiences on best practices in mentoring. 

Commitment to Diversity: I am committed to diversifying academia and ensuring fairness in policies and practices. I have long fought for improvements in our local environment for women and underrepresented minorities through University wide committees (Pay Equity and Women Faculty committees) and in leadership roles (e.g. President of the Academic Women's Network). I participate as a mentor in several undergraduate research training programs that focus on underrepresented group in academia (e.g. ENDURE, MARC u-STAR) and attend structured learning experiences (diversity training, mentoring diverse students, diversity book clubs) in order to educate myself in these areas.

Selected Publications:

Mauras N, Buckingham B, White NH,
Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey
T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P,
Marzelli M, Reiss AL; Diabetes Research in Children Network (DirecNet). Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal
Study. Diabetes Care. 2021
Apr;44(4):983-992. doi: 10.2337/dc20-2125. Epub 2021 Feb 10. PMID: 33568403

Ly M, Raji CA, Yu GZ, Wang Q, Wang
Y, Schindler SE, An H, Samara A, Eisenstein SA, Hershey T, Smith G, Klein S,
Liu J, Xiong C, Ances BM, Morris JC, Benzinger TLS. Obesity and White Matter
Neuroinflammation Related Edema in Alzheimer's Disease Dementia Biomarker
Negative Cognitively Normal Individuals. J Alzheimers Dis.
2021;79(4):1801-1811. doi: 10.3233/JAD-201242. PMID: 33459647

Younce JR, Campbell MC, Hershey
T, Tanenbaum AB, Milchenko M, Ushe M, Karimi M, Tabbal SD, Kim AE, Snyder AZ,
Perlmutter JS, Norris SA. Resting-State Functional Connectivity Predicts STN DBS Clinical Response.
Mov Disord. 2021 Mar;36(3):662-671. doi: 10.1002/mds.28376. Epub 2020 Nov 19. PMID: 33211330 

Samara A, Lugar HM, Hershey T,
Shimony JS. Longitudinal
Assessment of Neuroradiologic Features in Wolfram Syndrome. AJNR Am J
Neuroradiol. 2020 Dec;41(12):2364-2369. doi: 10.3174/ajnr.A6831. Epub 2020 Oct
29. PMID: 33122205

Samara A, Murphy T, Strain J, Rutlin
J, Sun P, Neyman O, Sreevalsan N, Shimony JS, Ances BM, Song SK, Hershey T,
Eisenstein SA (2020). Neuroinflammation and white matter alterations in obesity
assessed by diffusion basis spectrum imaging. Front Hum Neurosci; 13:
464. PMCID: PMC6971102

Sherafati A, Snyder AZ, Eggebrecht
AT, Bergonzi K, Burns-Yocum TM, Luger HM, Ferradal SL, Robichaux-Viehoever A,
Smyser CD, Palanca BJ, Hershey T, Culver JP (2020). Global motion detection and
censoring in high-density diffuse optical tomography. Hum Brain Mapp; 41(14):
4093-112. doi: 10.1002/hbm.25111. PMID: 32648643

Lugar HM, Koller JM, Rutlin J,
Eisenstein SA, Neyman O, Narayanan A, Chen L, Shimony JS, Hershey T (2019).
Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome
using longitudinal morphometry. Sci Rep; 9(1): 6010.
PMCID: PMC6461605

Samara A, Rahn R,
Neyman O, Park K, Samara A, Marshall B, Dougherty J, Hershey T (2019). Developmental
hypomyelination in Wolfram Syndrome: New insights from neuroimaging and gene
expression analyses. Orphanet J Rare Dis_; 14(1): 279. PMCID: PMC6889680

Fox LA, Hershey T,
Mauras N, Arbelaez AM, Tamborlane WV, Buckingham B, Tsalikian E, Englert K,
Raman M, Jo B, Shen H, Reiss A, Mazaika P, Diabetes Research in Children
Network (DirecNet) (2018). Persistence of abnormalities in white matter in
children with type 1 diabetes. Diabetologia; 61(7): 1538-47. PMCID: PMC5991628

Saggar M, Tsalikian E, Mauras N,
Mazaika P, White NH, Weinzimer S, Buckingham B, Hershey T, Reiss AL and the
Diabetes Research in Children Network (DirecNet) (2017).  Compensatory hyperconnectivity in developing
brains of young children with type 1 diabetes. Diabetes; 66(3): 754-62.
PMCID: PMC5319714

Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM,
Perlmutter JS, Black KJ, Hershey T (2016). Sweet dopamine: Sucrose preferences relate
differentially to striatal D2 receptor binding and age in obesity. Diabetes;
65(9): 2618-23. PMCID: PMC5001180

Lugar HM, Koller JM, Rutlin J, Marshall BA,
Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University
Wolfram Syndrome Research Study Group (2016). Neuroimaging evidence of
deficient axon myelination in Wolfram syndrome. Sci Rep; 6: 21167. doi: 10.1038/srep21167. PMCID:

Eggebrecht AT,
Ferradal SL, Robichaux-Viehoever A, Hassanpour MS, Dehghani H, Snyder AZ, Hershey
T, Culver JP (2014). Mapping distributed brain function and networks with
diffuse optical tomography. Nat Photonics; 8(6): 448-54. PMCID:

Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM,
Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T (2013). _A comparison of
D2 receptor specific binding in obese and normal-weight individuals using PET
with (N-[11 C]methyl)benperidol.
Synapse 67(11): 748-56.
PMCID: PMC3778147

Hershey T, Lugar H, Shimony J, Rutlin J,
Koller JM, Perantie DC, Paciorkowski AR, Eisenstein SA, Permutt MA, the
Washington University Wolfram Study Group (2012). Early brain vulnerability in
Wolfram syndrome. PLoS One; 7(7): e40604. PMCID: PMC3394712

Perantie D, Koller J,
Weaver P, Lugar HM, Black KJ, White NH, Hershey T (2011). Prospectively
determined impact of type 1 diabetes on brain volume during development. Diabetes;
60(11): 3006-14. PMCID: PMC3198062

Perantie D, Wu J, Lim A, Warren S, Koller J,
Black KJ, Hershey T (2007). Regional brain volume differences associated with
severe hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes
Care; 30(9): 2331-7. PMID: 17575089

Hershey T, Revilla F, Gibson PS, Wernle A,
Dowling J, Perlmutter JS (2004). Stimulation of STN impairs aspects of
cognitive control in PD. Neurology; 62(7):
1110-4. PMID: 15079009

Hershey T, Revilla F, Loepker A,
McGee-Minnich L, Antenor J, Videen T, Mink JW, Perlmutter JS (2003). Cortical
and subcortical blood flow effects of subthalamic nucleus stimulation in PD. Neurology;
61(6): 816-21. PMID: 14504327

Hershey T, Black KJ,
Stambuk MK, Carl JL, McGee-Minnich L., Perlmutter JS (1998). Altered thalamic response to levodopa in Parkinson’s
patients with dopa-induced dyskinesias. Proc
Natl Acad Sci; 95(20): 12016-21. PMCID:

Last Updated: 3/25/2021 10:34:31 AM

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