Craig Micchelli, Ph.D.

Associate Professor
Developmental Biology

Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-362-7036

  • 328 McDonnell Sciences Building

  • micchelli@wustl.edu

  • http://micchellilab.wustl.edu

  • cancer, Drosophila, regeneration, stem cells

  • The biology of stem cells

Research Abstract:

Stem cells constitute an essential reservoir of renewal potential conserved during evolution. The defining properties of self-renewal and multipotency make stem cells ideally suited for a central role in the generation of new cells during the lifetime of an organism. Our laboratory investigates the basis of stem cell behavior in their native tissue microenvironments. We use the powerful molecular, genetic and cell lineage tracing methodologies available only in the fruit fly, Drosophila melanogaster, to dissect the mechanisms controlling stem cell activity during the processes of development, regeneration and disease. In this way, we hope to define the core principles and regulatory circuitry that govern stem cell behavior. Such advances may ultimately translate into novel regenerative medicine therapies.

Selected Publications:

Lee WC, Beebe K, Sudmeier L, Micchelli CA. Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 2009 Jul; 136(13):2255-64. PMID: 19502486

Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006 Jan 26;439(7075):475-9. Epub 2005 Dec 7. PMID: 16340959

Last Updated: 8/4/2011 10:57:00 AM

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