Feng Chen, Ph.D.

Associate Professor
Internal Medicine
Cell Biology and Physiology

Developmental, Regenerative and Stem Cell Biology Program

  • 314-362-3162

  • 314-362-4309

  • 314-362-8237

  • 660 S. Euclid, Rm 7718 Wohl Clinic Bldg

  • fchen@dom.wustl.edu

  • http://chenlab.im.wustl.edu/

  • Cell-signaling, Development, Functional genomics, Molecular genetics, Renal disease, Transgenic, Cancer

  • Molecular genetic studies of urogenital diseases

Research Abstract:

Our laboratory studies the genetic determinants and pathogenic mechanisms of urogenital diseases with the goal of improving diagnostic and therapeutic strategies targeting these diseases. We have been creating and utilizing an array of experimental and disease models in mice to study the involvement of a number of pathways (such as the calcineurin/NFAT and Wnt signaling pathways) in urogenital diseases (such as Congenital anomalies of the kidney and the urinary tract (CAKUT), glomerular diseases, and prostate cancer). We use a multi-disciplinary approach, including cutting edge genome technologies, to study the mechanisms leading from defined genetic changes to the development of benign and malignant diseases in urogenital organs. While we take advantage of the in vivo systems for studying the genetic, physiological, and pathological aspects of these diseases, we also performed experiments in ex vivo and in vitro systems to study molecular interactions and cellular behaviors, using molecular biology, cell biology and biochemistry techniques. In addition to answering specific questions with clinical relevance, we are also keen on developing new genetic tools for the research community, such as new tissue-specific Cre transgenes and conditionally controllable transgenic mouse lines.

Selected Publications:

Piyush Tripathi, Yinqiu Wang, Matthew Coussens, Kalyan R. Manda, Adam M. Casey, Congxing Lin, Edward Poyo, John D. Pfeifer, Nisha Basappa, Carlton M. Bates, Liang Ma, Hong Zhang, Minggui Pan, Li Ding, Feng Chen (2013)
Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms
Oncogene (Epub ahead of print) April 29, 2013.

Li Ding, Benjamin J. Raphael, Feng Chen, Michael C. Wendl (2013)
Advances for Studying Clonal Evolution in Cancer
Cancer Letters (Epub ahead of print ) Jan 23, 2013.

M.-G. Pan, Y. Xiong, and F. Chen (2012)
NFAT Gene Family in Inflammation and Cancer
Current Molecular Medicine 13(4):543-5 PMID:22950383 PMC3694398

Feng Chen and Li Ding (2012)
Co-Survival of the Fittest Few - Mosaic Amplification of Receptor Tyrosine Kinases in Glioblastoma
Genome Biology 13:141

Qiusha Guo, Bing Xia, Feng Zhang, Mekel M. Richardson, Minghao Li, Julian S. Zhang, Feng Chen, Xin A. Zhang (2012)
Tetraspanin CO-029 Inhibits Colorectal Cancer Cell Movement by Deregulating Cell-Matrix and Cell-Cell Adhesions
PLoS ONE 7(6): e38464

Piyush Tripathi, Yinqiu Wang, Adam M. Casey, Feng Chen (2012)
Absence of canonical Smad signaling in the bladder and ureter mesenchyme causes UPJ obstruction
Journal of American Society of Nephrology 23: 618-628

Qiusha Guo, Piyush Tripathi, Edward Poyo, Yinqiu Wang, Paul F. Austin, Carlton M. Bates, Feng Chen (2011)
Cell death serves as a single etiological cause for a wide spectrum of congenital urinary tract defects
Journal of Urology 185, p2320-2328

Yinqiu Wang, George Jarad, Piyush Tripathi, Minggui Pan, Jeanette Cunningham, Daniel R. Martin, Helen Liapis, Jeffrey H. Miner, and Feng Chen (2010)
Activation of NFAT signaling in podocytes causes glomerulosclerosis
Journal of American Society of Nephrology 21 (10): 1657. Epub July 2010

Piyush Tripathi, Qiusha Guo, Yinqiu Wang, Matthew Coussens, Helen Liapis, Sanjay Jain, Michael R Kuehn, Mario R Capecchi, Feng Chen (2010)
Midline Signaling Regulates Kidney Positioning but not Nephrogenesis through Shh
Developmental Biology 40(2):518-27. Epub 2010 Feb 10.

Feng Chen (2009)
Genetic and developmental basis for urinary tract obstruction
Pediatric Nephrology 24 (9) 1621-32.

Yinqiu Wang, Piyush Tripathi, Qiusha Guo, Matthew Coussens, Liang Ma and Feng Chen (2009)
Cre/Lox Recombination in the Lower Urinary Tract
Genesis 47 (6): 409-413.

Song-Zhe Li, Bradley W. McDill, Paul A. Kovach, Li Ding, William Y. Go, Steffan N. Ho, Feng Chen. (2007)
Coordinate regulation of AQP2 expression by the calcineurin-NFATc pathway and the TonEBP/NFAT5 osmotic stress response
American Journal of Physiology Cell Physiology 292: C1606-C1616.

Bradley W. McDill, Song-Zhe Li, Paul A. Kovach, Li Ding, Feng Chen. (2006)
Cph (congenital obstructive hydronephrosis) is caused by an S256L mutation in AQP2 that affects its phosphorylation and apical membrane incorporation
Proceedings of the National Academy of Sciences 103:18, 6952-6957.

Chingpin Chang, Bradley W. McDill, Joel R. Neilson, Heidi E. Joist, Jonathan A. Epstein, Gerald R. Crabtree, Feng Chen. (2004)
Calcineurin is Required in Urinary Tract Mesenchyme for the Development of the Pyeloureteral Peristaltic Machinery
Journal of Clinical Investigation 113:7, 1051-1058. (Commentary on Journal of Clinical Investigation 2004 113: 957-959. Functional obstruction: the renal pelvis rules by Cathy Mendelsohn).

Last Updated: 7/30/2013 10:14:06 AM

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