Albert H. Kim, M.D., Ph.D.

Associate Professor
Neurosurgery
Genetics
Neurology

Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Neurosciences Program
Cancer Biology Program

  • 314-747-6141

  • 314-747-6360

  • 314-362-2107

  • kima@wudosis.wustl.edu

  • albertkimlab.com

  • brain tumors, glioblastoma, meningioma, neural stem cells

  • Genetic and epigenetic changes that drive malignant behavior in brain tumors

Research Abstract:

Despite advances in multimodal therapies, malignant brain tumors continue to be devastating neurological diseases. The proliferation of recent genome-wide surveys in brain tumors has led to the important identification of tumor-specific abnormalities, which are only beginning to be understood at the functional, biological level. The goal of my laboratory is to use combined genomic and epigenetic approaches to identify "hardwired" molecular targets that drive malignant brain tumor growth and invasiveness. Potentially, these discoveries could be leveraged clinically to generate novel therapies for patients.

Selected Publications:

Mahlokozera T, Vellimana AK, Li T, Mao DD, Zohny ZS, Kim DH, Tran DD, Marcus DS, Fouke SJ, Campian JL, Dunn GP, Miller CA, Kim AH. Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma. Neuro Oncol. 2018 Mar 27;20(4):472-483. PubMed PMID: 29244145; PubMed Central PMCID: PMC5909635.

Huang J, Campian JL, Gujar AD, Tsien C, Ansstas G, Tran DD, DeWees TA, Lockhart AC, Kim AH. Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2018 May;138(1):105-111. PubMed PMID: 29374809.

Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M. Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell. 2018 Jan 25;172(3):534-548.e19. PubMed PMID: 29275861.

Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8247-E8256. PubMed PMID: 27930300; PubMed Central PMCID: PMC5187672.

Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH. A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells. Cell Rep. 2015 Jun 23;11(11):1809-21. PubMed PMID: 26074073; PubMed Central PMCID: PMC4481182.

Puram SV,* Kim AH,*# Park H, Anckar J, Bonni A.# The Ubiquitin Receptor S5a/Rpn10 Links Centrosomal Proteasomes with Dendrite Development in the Mammalian Brain. Cell Reports. In press. (*contributed equally; #corresponding author)

S.V. Puram, A.H. Kim, Y. Ikeuchi, A. Riccio, S. Koirala, J.T. Wilson-Grady, A. Merdes, S.P. Gygi, G. Corfas, and A. Bonni. A Unique CaMKIIβ Signaling Pathway at the Centrosome Regulates Dendrite Patterning in the Mammalian Brain. Nat Neurosci. 14(8):973-83.2011.

Y. Yang, A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, and A. Bonni. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326:575-8. 2009.

A.H. Kim, S.V. Puram, P.M. Bilimoria, S. Keough, M. Wong, D. Rowitch, and A. Bonni. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 136(2):322-336. 2009.

A.H. Kim, H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J. Birnbaum, and M.V. Chao. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35(4): 697-709. 2002.

Last Updated: 1/30/2019 1:04:05 PM

Cell-intrinsic and -extrinsic control of glioblastoma stem-like cells
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