Gwendalyn J Randolph, Ph.D.

Emil R. Unanue Professor
Pathology and Immunology
Internal Medicine

Immunology Program
Molecular Microbiology and Microbial Pathogenesis Program

Research Abstract:

Our laboratory considers the impact of how transit of cells and molecules out of tissues influences the inflammatory microenvironment. The lymphatic vasculature is the primary regulator of flux out of tissues and thus we focus on the functionality of the lymphatic vasculature as it relates to the transport of cargo, particularly myeloid antigen-presenting cells in immunity and molecular entities like HDL. In this context, we focus on two chronic inflammatory disease settings, experimental atherosclerosis and inflammatory bowel disease.

Selected Publications:

YH Han, EJ Onufer, RW Sprung, WS Davidson, RS Czepielewski, M Wohltmann, MG Sorci-Thomas, BW Warner, GJ Randolph. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein, Science, 373, 410; DOI: 10.1126/science.abe6729

O Baba, A Elvington, D Sultan, GS Heo, X Zhang, H Luehmann, L Detering, M Szpakowska, A Chevigne, Y Liu, GJ Randolph. 2021. CXCR4 on atherosclerotic plaque endothelium predicts the magnitude of monocyte recruitment and is readily targeted by PET tracers. Arterio Thromb Vasc Biol 41(2):822-836. doi: 10.1161/ATVBAHA.120.315053. [editorial comment, same issue]

LH Huang, P Deepak, MA Ciorba, B Mittendorfer, BW Patterson, GJ Randolph. 2020. Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn’s disease. Gastroenterology, 159:1955-9156. doi: 10.1053/j.gastro.2020.07.012

JW Williams, K Zaitsev, KW Kim S Ivanov, BT Saunders, PR Schrank, K Kim, A Elvington, SH Kim, C Tucker, M Wohltmann, BT Fife, S Epelman, M Artyomov, KJ Lavine, BH Zinselmeyer, JH Choi, GJ. Randolph. Limited proliferation capacity of aorta intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression, Nature Immunology, 21:1194-1204. doi. 10.1038/s41590-020-0768-4

PL Wang, AKY Yim, K Kim, D Avey, RS Czepielewski, M Colonna, *J Milbrandt, *GJ Randolph.. 2020. Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia. Nature Communications, 11(1):2552. doi: 10.1038/s41467-020-16355-w (* joint corresponding authors)

Zhang N, Czepielewski RS, Jarjour NN, Erlich EC, Esaulova E, Saunders BT, Grover SP, Cleuren AC, Broze GJ, Edelson BT, Mackman N, Zinselmeyer BH, Randolph GJ. (2019). Expression of factor V by resident peritoneal macrophages boosts host defense in the peritoneal cavity. J. Exp. Med, 216: 1291-6. [cover feature] PMCID 6547866

Angeli V, Ginhoux F, Llodrá J, Quemeneur L, Frenette PS, Skobe M, Jessberger R, Merad M, and Randolph GJ. B cell driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 2006;24(2):203-215. [cover feature and commentary]. PMID: 16473832

Last Updated: 7/25/2021 9:14:35 PM

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