David D. Limbrick, M.D., Ph.D.


Neurosciences Program

  • 314-454-4454

  • limbrickd@WUSTL.EDU

  • Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine

  • We study disorders of cerebrospinal fluid (CSF) physiology such as hydrocephalus and Chiari-associated syringomyelia

Research Abstract:

In our laboratory, we study disorders of cerebrospinal fluid (CSF) physiology such as hydrocephalus and Chiari-associated syringomyelia. We employ a broad range of experimental methodologies - from CSF analysis to advanced MRI - to examine these common and important clinical problems. We work to bring together complementary expertise and experience to conduct multi-modality, multi-disciplinary, and often multi-institutional collaborative research.

Selected Publications:

Limbrick, D.D.J., Churn, S.B., Sombati, S., and DeLorenzo, R.J. Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death. Brain Research 690: 145-56, 1995.

Churn, S.B., Limbrick, D., Sombati, S., and DeLorenzo, R.J. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. Journal of Neuroscience 15: 3200-14, 1995.

DeLorenzo, R.J. and Limbrick, D.D.J. Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons. Advances in Neurology 71: 37-46, 1996.

Pal, S., Sombati, S., Limbrick, D.D.J., and DeLorenzo, R.J. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Research 851: 20-31, 1999.

Pal, S., Limbrick, D.D.J., Rafiq, A., and DeLorenzo, R.J. Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium 28: 181-93, 2000.

Last Updated: 8/2/2017 3:39:42 PM

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