Kareem Azab, Ph.D.

Associate Professor
Radiation Oncology
Cancer Biology

Molecular Cell Biology Program
Immunology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-9254

  • 747-5452

  • (314) 362-9790

  • 4511 Forest Park Ave., MO, 63108

  • aazab@WUSTL.EDU

  • http://radonc.wustl.edu/research/cancerbio/azab/

  • Drug Delivery, Cancer Stem Cells, Drug Resistance, Multiple Myeloma, Bone Marrow Microenvironment, Breast Cancer, Biodegradable Polymers, Nanoparticles

  • We investigate the mechanisms of neoplasia and metastasis, and develop targeted drug-delivery-systems for cancer treatment.

Research Abstract:

The research in our Lab involves both basic and translational approaches:

Our basic research approach focuses on understanding the proliferation and metastasis processes in cancer including multiple myeloma, lymphoma and others. We are interested in understanding the mechanism involved in cell trafficking of cancer cells during proliferation metastasis. Particularly we are interested in the role of hypoxia and adhesion-molecules in promoting metastasis and drug resistance in these cancers. Our understanding of these mechanisms will help us design and develop novel drugs and therapeutic strategies which will be translated from-bench-to-bed.

Our translational approach focuses development of targeted-nano-particulate drug delivery systems in hematological malignancies. Moreover, we are interested in development of natural and synthetic polymers as drug carriers; which includes soluble polymers for systemic delivery and hydrogels for local delivery. This approach is to increase the efficacy of the treatment and to reduce side effects.

Selected Publications:

1. Azab, A.K. et al. (2013). The influence of hypoxia on CML trafficking through modulation of CXCR4 and E‐cadherin expression. Leukemia, In Press. (PMID 23212153)
2. Azab, A.K. et al. (2012). Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition‐like features. Blood. 119(24):5782‐94. (PMID 22394600)
3. Azab, A.K. et al. (2012). P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment. Blood. 119(6):1468‐78. (PMID 22096244)
4. Azab, A.K. et al. (2012). Eph‐B2/ephrin‐B2 interaction plays a major role in the adhesion and survival of WM cells in the context of the bone marrow microenvironment. Clin Cancer Res. 18(1):91‐104. (PMID 22010211)
5. Azab, A.K. et al. (2011). FGFR3 is overexpressed in Waldenstrm macroglobulinemia and its inhibition by Dovitinib induces apoptosis, and overcomes stroma‐induced proliferation. Clin Cancer Res. 17(13):4389‐99. (PMID 21521775)
6. Azab, A.K. et al. (2009). RhoA and Rac1 GTPases play major and differential roles in stromal cell‐derived factor‐1‐induced cell adhesion and chemotaxis in multiple myeloma. Blood. 114(3):619‐29. (PMID 19443661)
7. Azab, A.K. et al. (2009). The CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood. 113(18):4341‐51. (PMID 19139079 )
8. Azab, A.K. et al. (2008). The Metastatic Stage‐dependent Mucosal Expression of Sialic Acid is a Potential Marker for Targeting Colon Cancer with Cationic Polymers. Pharm Res. 25(2):379‐86. (PMID 17960470)
9. Azab, A.K. et al. (2007) Prevention of tumor recurrence and distant metastasis formation in a breast cancer mouse model by biodegradable implant of 131I‐norcholesterol. J Control Release. 123(2):116‐22. (PMID 17854940)
10. Azab, A.K. et al. (2005)Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers. J Control Release. 106(1‐2):14‐25. (PMID 16005094)

Last Updated: 2/1/2013 11:29:13 AM

The role of hypoxia, induced by tumor progression, in the metastasis of multiple myeloma
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