Irfan J. Lodhi, Ph.D.

Associate Professor
Internal Medicine
Endocrinology/Metabolism

Molecular Cell Biology Program
Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-747-6766

  • 314-747-6473

  • 314-362-7641

  • 815J Southwest Tower

  • ilodhi@wustl.edu

  • https://www.lodhilab.org

  • Adipose tissue, brown fat, diabetes, obesity, lipid metabolism, peroxisomes, mitochondria

  • Role of lipid metabolism in obesity, diabetes and other metabolic diseases

Research Abstract:

The research in our laboratory is centered on understanding lipid metabolism pathways and their relationship to metabolic diseases, such as diabetes and obesity. We are especially interested in how peroxisomes, organelles specialized for lipid metabolism, channel lipids to discrete subcellular compartments to influence metabolism. Using a variety of innovative approaches, including lipidomics, proteomics and gene expression profiling, we have uncovered metabolic links between peroxisomes and other organelles affecting adipose tissue biology and hepatic lipid metabolism. Current studies are focused on understanding how peroxisomal lipid metabolism affects mitochondrial dynamics, lysosomal degradation of lipid droplets (lipophagy) and gene expression in various metabolic tissues.

Selected Publications:

He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JD, Razani B, Lodhi IJ (2020). Acetyl-CoA Derived from Hepatic Peroxisomal Beta-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Molecular Cell 79(1):30-42.

Zhang X, Sergin I, Evans TD, Jeong S, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B (2020). High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Nature Metabolism 2(1):110-125.

Evans TD, Zhang X, Jeong SJ, He A, Bhattacharya S, Song E, Holloway KB, Lodhi IJ, Razani B (2019). TFEB drives Adipocyte PGC-1α to protect against Diet-Induced Metabolic Dysfunction. Science Signaling 12(606): eaau2281. DOI: 10.1126/scisignal.aau228

Park H, He A, Lodhi IJ (2019). Lipid Regulators of Thermogenic Fat Activation. Trends in Endocrinology & Metabolism 30(10): 710-723.

Park H, He A, Tan M, Dean JM, Johnson JM, Chen Y, Zhang X, Hsu FF, Razani B, Funai F, and Lodhi IJ (2019). Peroxisome-Derived Lipids Regulate Adipose Thermogenesis by Mediating Cold-Induced Mitochondrial Fission. Journal of Clinical Investigation, 129(2):694-711.

Cipolla CM and Lodhi IJ (2017). Peroxisomal Dysfunction in Age-Related Diseases. Trends in Endocrinology & Metabolism 28(4): 297-308.

Lodhi IJ#, Dean JM, He A, Park H, Tan M, Feng C, Song H, Hsu FF, Semenkovich CF (2017). PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Reports 20: 2766-2774. #Corresponding author

Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu F, Link DC, Semenkovich CF (2015). Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability. Cell Metabolism 21(1): 51-64.

Lodhi IJ and Semenkovich CF (2014). Peroxisomes: a Nexus for Lipid Metabolism and Cellular Signaling. Cell Metabolism 19(3): 380-392.

Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, and Semenkovich CF (2012). Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Cell Metabolism 16(2): 189-201.

Last Updated: 9/14/2020 12:18:19 PM

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