Simon Haroutounian, Ph.D., M.Sc.

Assistant Professor
Anesthesiology

Neurosciences Program

  • 314-286-1715

  • sharout@wustl.edu

  • Dr. Haroutounian studies neuropathic pain with a focus on determining individual predictors of treatment response to analgesic pharmacotherapy.

Research Abstract:

Pain is one of the leading causes of disability worldwide, and is the single most common reason people seek medical care. While acute pain episodes are typically time-limited and can be treated reasonably well in most cases, chronic pain - which affects about 20% of the adult population - is largely undertreated. Especially challenging is neuropathic pain, a consequence of damage or disease affecting the central or the peripheral nervous systems.

Chronic pain may be related to concomitant medical conditions (e.g. diabetes, stroke, multiple sclerosis or cancer), be of unknown origin, or be a result of a treatment such as surgery or chemotherapy, that was aimed to cure a disease or improve patients’ quality of life.

It is an enormous and costly effort to match the right analgesic treatment (or combination of treatments) to the right patient – the therapy that will allow good pain relief and improved quality of life, but will not cause side effects. Currently, this individual treatment “tailoring” is more of an art than a science.

By applying translational research, we explore methods to prevent chronic pain when possible, and to make the individualized pain management a science.

Selected Publications:

Haroutounian S, Ford AL, Frey K, Nikolajsen L, Finnerup NB, Neiner A, Kharasch ED, Karlsson P, Bottros M. "How central is central post-stroke pain? The role of afferent input in post-stroke neuropathic pain". PAIN 2018 (in press).

Hwang CT, Van Dillen LR, Haroutounian, S. "Do Changes in Sensory Processing Precede Low Back Pain Development in Healthy Individuals?" Clin J Pain 2018: 34(6).

Meacham K, Shepherd A, Mohapatra DP, Haroutounian S. "Neuropathic Pain: Central vs. Peripheral Mechanisms". Current Pain and Headache Reports. 2017; 21(6)

Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice AS, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. “Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations” PAIN 2016.

Last Updated: 8/21/2018 10:46:07 AM

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