Hong Chen, Ph.D.

Associate Professor
Biomedical Engineering
Radiation Oncology

Molecular Cell Biology Program
Neurosciences Program

  • 314-454-7742

  • 4511 Forest Park Avenue - Medical Campus Lab, Room 200B

  • hongchen@wustl.edu

  • Combines biology, engineering, and medicine to develop ultrasound techniques for noninvasive, targeted, and personalized cancer treatment

Research Abstract:

Hong Chen`s research focuses on medical ultrasound. Her goal is to develop image-guided ultrasound therapy techniques for cancer therapy through combining the diagnostic and therapeutic functions of ultrasound, integrating physical acoustics with the development of medical ultrasound devices, and bridging basic and translational research.

Selected Publications:

1. Kothapalli S., Altman M., Wan L., Partanen A., Gach HM, Straube W., Hallahan D., and Chen H.(2017) Acoustic field calibration of a clinical magnetic resonance-guided high-intensity focused ultrasound system inside the magnet bore, Medical Physics

2. Kamimura H, Wang ST, Chen H, Wang Qi, Aurup C, Acosta C, Carneiro A, and Konofagou E (2016), Noninvasive focused ultrasound for cognitive- and motor-related brain modulation, Medical Physics. 43(10): 5730-5735.

3. Chen H, Yang G, Getachew H, Acosta CJ, Sierra Sánchez CJ, Konofagou EE (2016), Focused ultrasound-enhanced intranasal brain drug delivery of the brain-derived neurotrophic factor. Scientific Reports. 6:28599

4. Chen H, Han Y, Payen T, Palermo CF, Olive KP, Konofagou EE (2015), Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: a feasibility study in a transgenic mouse model of pancreatic cancer. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 62(9):1662-73

5. Li T, Wang Y-N, Khokhlova T, D’Andrea S, Starr F, Chen H, McCune JS, Risler LJ, Mashadi-Hossein A, Hwang JH (2015), Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in the KPC mouse model of pancreatic cancer. Cancer Research. canres-0296.

6. Chen H, Chen C, Wu SY, Tao Su, Acosta C, Konofagou EE (2014). A new brain drug delivery strategy: Focused ultrasound-enhanced intranasal drug delivery. PLoS ONE. 9(10): e108880

7. Chen H, Konofagou EE (2014). The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure. Journal of cerebral blood flow and metabolism. 34(7):1197–1204

8. Li T, Chen H, Khokhlova TD, Wang YN, Kreider W, He XM, Hwang JH (2014), Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumors. Ultrasound in Medicine and Biology. 40(7): 1523-1534

9. Chen H, Brayman AA, Matula TJ (2012). Characteristic microvessel relaxation timescales associated with ultrasound-activated microbubbles. Applied Physics Letters. 101(16): 163704|

10. Chen H, Kreider W, Brayman AA, Bailey MR, Matula TJ (2011). Blood vessel deformations on microsecond time scales by ultrasonic cavitation. Physical Review Letters. 106(3): 034301.

Last Updated: 9/18/2017 9:22:58 AM

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