Farshid Guilak, Ph.D.

Orthopaedic Surgery

Developmental, Regenerative and Stem Cell Biology Program
Molecular Cell Biology Program
Immunology Program

  • 314 362-8605

  • guilak@wustl.edu

  • Focuses on the role of biomechanical factors in the onset, progression, and treatment of osteoarthritis and other joint diseases.

Research Abstract:

Dr. Guilak’s laboratory focuses on the role of biomechanical factors in the onset, progression, and treatment of osteoarthritis and other joint diseases. These based studies are being performed from the cellular and
subcellular level, to that of the whole body, to better understand the interaction of biomechanical factors with
genetic, biochemical, and other environmental influences. In the context of this application, Dr. Guilak’s work
is currently focusing on several different aspects of osteoarthritis and other chronic joint diseases. These
studies are designed to determine the interactions between biomechanical loading and cellular response under
normal and pathological conditions such as injury or obesity to find new pharmacologic targets. His research
also focuses on the application of adult or induced pluripotent stem cells for tissue- engineered repair and cellbased therapies for degenerative and autoimmune diseases of the musculoskeletal system. Ongoing research
in this area focuses on the development of “smart” cells that have been modified using the CRISPR/Cas9
system to produce therapeutic drugs to treat metabolic or inflammatory disorders. He serves as the Editor-in-
Chief of the Journal of Biomechanics and Associate Editor for Osteoarthritis & Cartilage. Dr. Guilak has had a
long history of training graduate students and postdocs, and previously served as director of a NIH T32 grant.
He has received three separate mentoring awards, including those from the graduate school, medical school,
the postdoctoral society at Duke University.

Selected Publications:

Guilak F, Mow VC. The mechanical environment of the chondrocyte: a biphasic finite element model of cellmatrix
interactions in articular cartilage. J Biomech. 2000 Dec;33(12):1663-73.

Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. Osteoarthritic changes in the biphasic
mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech.

Widmyer MR, Utturkar GM, Leddy HA, Coleman JL, Spritzer CE, Moorman CT 3rd, DeFrate LE, Guilak F. High
body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis
Rheum. 2013 ;65(10):2615-22. PMCID: PMC3954747.

Guilak F, Butler DL, Goldstein SA, Baaijens FP. Biomechanics and mechanobiology in functional tissue
engineering. J Biomech. 2014 Jun 27;47(9):1933-40. PMCID:4051419.

Last Updated: 8/21/2018 8:48:43 AM

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